Pickering DS - Search Results

1

Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters.

Assaf Z, Larsen AP, Venskutonytė R, Han L, Abrahamsen B, Nielsen B, Gajhede M, Kastrup JS, Jensen AA, Pickering DS, Frydenvang K, Gefflaut T, Bunch L. Assaf Z, et al. Among authors: pickering ds. J Med Chem. 2013 Feb 28;56(4):1614-28. doi: 10.1021/jm301433m. Epub 2013 Feb 15. J Med Chem. 2013. PMID: 23414088

2

Pharmacological properties of homomeric and heteromeric GluR1o and GluR3o receptors.

Nielsen BS, Banke TG, Schousboe A, Pickering DS. Nielsen BS, et al. Among authors: pickering ds. Eur J Pharmacol. 1998 Nov 6;360(2-3):227-38. doi: 10.1016/s0014-2999(98)00668-2. Eur J Pharmacol. 1998. PMID: 9851590

3

Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).

Bjerrum EJ, Kristensen AS, Pickering DS, Greenwood JR, Nielsen B, Liljefors T, Schousboe A, Bräuner-Osborne H, Madsen U. Bjerrum EJ, et al. Among authors: pickering ds. J Med Chem. 2003 May 22;46(11):2246-9. doi: 10.1021/jm020588f. J Med Chem. 2003. PMID: 12747796

4

Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues.

Valgeirsson J, Christensen JK, Kristensen AS, Pickering DS, Nielsen B, Fischer CH, Bräuner-Osborne H, Nielsen EØ, Krogsgaard-Larsen P, Madsen U. Valgeirsson J, et al. Among authors: pickering ds. Bioorg Med Chem. 2003 Oct 1;11(20):4341-9. doi: 10.1016/s0968-0896(03)00485-1. Bioorg Med Chem. 2003. PMID: 13129570

5

A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.

Vogensen SB, Greenwood JR, Varming AR, Brehm L, Pickering DS, Nielsen B, Liljefors T, Clausen RP, Johansen TN, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: pickering ds. Org Biomol Chem. 2004 Jan 21;2(2):206-13. doi: 10.1039/b310450h. Epub 2003 Nov 24. Org Biomol Chem. 2004. PMID: 14737644

6

Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2.

Frandsen A, Pickering DS, Vestergaard B, Kasper C, Nielsen BB, Greenwood JR, Campiani G, Fattorusso C, Gajhede M, Schousboe A, Kastrup JS. Frandsen A, et al. Among authors: pickering ds. Mol Pharmacol. 2005 Mar;67(3):703-13. doi: 10.1124/mol.104.002931. Epub 2004 Dec 9. Mol Pharmacol. 2005. PMID: 15591246

7

Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP.

Nielsen BB, Pickering DS, Greenwood JR, Brehm L, Gajhede M, Schousboe A, Kastrup JS. Nielsen BB, et al. Among authors: pickering ds. FEBS J. 2005 Apr;272(7):1639-48. doi: 10.1111/j.1742-4658.2005.04583.x. FEBS J. 2005. PMID: 15794751 Free article.

8

Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.

Vogensen SB, Clausen RP, Greenwood JR, Johansen TN, Pickering DS, Nielsen B, Ebert B, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: pickering ds. J Med Chem. 2005 May 5;48(9):3438-42. doi: 10.1021/jm050014l. J Med Chem. 2005. PMID: 15857151

9

4-Alkylated homoibotenic acid (HIBO) analogues: versatile pharmacological agents with diverse selectivity profiles towards metabotropic and ionotropic glutamate receptor subtypes.

Madsen U, Pickering DS, Nielsen B, Bräuner-Osborne H. Madsen U, et al. Among authors: pickering ds. Neuropharmacology. 2005;49 Suppl 1:114-9. doi: 10.1016/j.neuropharm.2005.05.007. Neuropharmacology. 2005. PMID: 15996690

10

The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209.

Kasper C, Pickering DS, Mirza O, Olsen L, Kristensen AS, Greenwood JR, Liljefors T, Schousboe A, Wätjen F, Gajhede M, Sigurskjold BW, Kastrup JS. Kasper C, et al. Among authors: pickering ds. J Mol Biol. 2006 Apr 7;357(4):1184-201. doi: 10.1016/j.jmb.2006.01.024. Epub 2006 Jan 31. J Mol Biol. 2006. PMID: 16483599

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