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SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.
Chen XW, Wang H, Bajaj K, Zhang P, Meng ZX, Ma D, Bai Y, Liu HH, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin J, Young SG, Schekman R, Ginsburg D. Chen XW, et al. Among authors: ginsburg d. Elife. 2013 Apr 9;2:e00444. doi: 10.7554/eLife.00444. Elife. 2013. PMID: 23580231 Free PMC article.
Murine SEC24D can substitute functionally for SEC24C during embryonic development.
Adams EJ, Khoriaty R, Kiseleva A, Cleuren ACA, Tomberg K, van der Ent MA, Gergics P, Tang VT, Zhu G, Hoenerhoff MJ, O'Shea KS, Saunders TL, Ginsburg D. Adams EJ, et al. Among authors: ginsburg d. Sci Rep. 2021 Oct 26;11(1):21100. doi: 10.1038/s41598-021-00579-x. Sci Rep. 2021. PMID: 34702932 Free PMC article.
Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.
Khoriaty R, Hesketh GG, Bernard A, Weyand AC, Mellacheruvu D, Zhu G, Hoenerhoff MJ, McGee B, Everett L, Adams EJ, Zhang B, Saunders TL, Nesvizhskii AI, Klionsky DJ, Shavit JA, Gingras AC, Ginsburg D. Khoriaty R, et al. Among authors: ginsburg d. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7748-E7757. doi: 10.1073/pnas.1805784115. Epub 2018 Jul 31. Proc Natl Acad Sci U S A. 2018. PMID: 30065114 Free PMC article.
The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
Wang B, Joo JH, Mount R, Teubner BJW, Krenzer A, Ward AL, Ichhaporia VP, Adams EJ, Khoriaty R, Peters ST, Pruett-Miller SM, Zakharenko SS, Ginsburg D, Kundu M. Wang B, et al. Among authors: ginsburg d. J Clin Invest. 2018 Aug 1;128(8):3319-3332. doi: 10.1172/JCI98194. Epub 2018 Jun 25. J Clin Invest. 2018. PMID: 29939162 Free PMC article.
328 results