Wang Z - Search Results

1

Molecular basis of sphingosine kinase 1 substrate recognition and catalysis.

Wang Z, Min X, Xiao SH, Johnstone S, Romanow W, Meininger D, Xu H, Liu J, Dai J, An S, Thibault S, Walker N. Wang Z, et al. Structure. 2013 May 7;21(5):798-809. doi: 10.1016/j.str.2013.02.025. Epub 2013 Apr 18. Structure. 2013. PMID: 23602659 Free article.

2

Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper.

Wang Z, Liu J, Sudom A, Ayres M, Li S, Wesche H, Powers JP, Walker NP. Wang Z, et al. Structure. 2006 Dec;14(12):1835-44. doi: 10.1016/j.str.2006.11.001. Structure. 2006. PMID: 17161373 Free article.

3

Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.

Tu H, Powers JP, Liu J, Ursu S, Sudom A, Yan X, Xu H, Meininger D, Degraffenreid M, He X, Jaen JC, Sun D, Labelle M, Yamamoto H, Shan B, Walker NP, Wang Z. Tu H, et al. Among authors: wang z. Bioorg Med Chem. 2008 Oct 1;16(19):8922-31. doi: 10.1016/j.bmc.2008.08.065. Epub 2008 Aug 29. Bioorg Med Chem. 2008. PMID: 18789704

4

Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).

Min X, Thibault ST, Porter AC, Gustin DJ, Carlson TJ, Xu H, Lindstrom M, Xu G, Uyeda C, Ma Z, Li Y, Kayser F, Walker NP, Wang Z. Min X, et al. Among authors: wang z. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7379-84. doi: 10.1073/pnas.1016167108. Epub 2011 Apr 18. Proc Natl Acad Sci U S A. 2011. PMID: 21502526 Free PMC article.

5

Crystal structure of a single-chain trimer of human adiponectin globular domain.

Min X, Lemon B, Tang J, Liu Q, Zhang R, Walker N, Li Y, Wang Z. Min X, et al. Among authors: wang z. FEBS Lett. 2012 Mar 23;586(6):912-7. doi: 10.1016/j.febslet.2012.02.024. Epub 2012 Feb 22. FEBS Lett. 2012. PMID: 22449980 Free article.

6

Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction.

Chen X, Kopecky DJ, Mihalic J, Jeffries S, Min X, Heath J, Deignan J, Lai S, Fu Z, Guimaraes C, Shen S, Li S, Johnstone S, Thibault S, Xu H, Cardozo M, Shen W, Walker N, Kayser F, Wang Z. Chen X, et al. Among authors: wang z. J Med Chem. 2012 Apr 26;55(8):3837-51. doi: 10.1021/jm300037x. Epub 2012 Apr 18. J Med Chem. 2012. PMID: 22458568

7

Structure of the nuclear factor κB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation.

Liu J, Sudom A, Min X, Cao Z, Gao X, Ayres M, Lee F, Cao P, Johnstone S, Plotnikova O, Walker N, Chen G, Wang Z. Liu J, et al. Among authors: wang z. J Biol Chem. 2012 Aug 10;287(33):27326-34. doi: 10.1074/jbc.M112.366658. Epub 2012 Jun 20. J Biol Chem. 2012. PMID: 22718757 Free PMC article.

8

Structure guided design of a series of sphingosine kinase (SphK) inhibitors.

Gustin DJ, Li Y, Brown ML, Min X, Schmitt MJ, Wanska M, Wang X, Connors R, Johnstone S, Cardozo M, Cheng AC, Jeffries S, Franks B, Li S, Shen S, Wong M, Wesche H, Xu G, Carlson TJ, Plant M, Morgenstern K, Rex K, Schmitt J, Coxon A, Walker N, Kayser F, Wang Z. Gustin DJ, et al. Among authors: wang x, wang z. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4608-16. doi: 10.1016/j.bmcl.2013.06.030. Epub 2013 Jun 20. Bioorg Med Chem Lett. 2013. PMID: 23845219

9

The high-resolution crystal structure of human LCAT.

Piper DE, Romanow WG, Gunawardane RN, Fordstrom P, Masterman S, Pan O, Thibault ST, Zhang R, Meininger D, Schwarz M, Wang Z, King C, Zhou M, Walker NP. Piper DE, et al. Among authors: wang z. J Lipid Res. 2015 Sep;56(9):1711-9. doi: 10.1194/jlr.M059873. Epub 2015 Jul 20. J Lipid Res. 2015. PMID: 26195816 Free PMC article.

10

Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).

Min X, Ungureanu D, Maxwell S, Hammarén H, Thibault S, Hillert EK, Ayres M, Greenfield B, Eksterowicz J, Gabel C, Walker N, Silvennoinen O, Wang Z. Min X, et al. Among authors: wang z. J Biol Chem. 2015 Nov 6;290(45):27261-27270. doi: 10.1074/jbc.M115.672048. Epub 2015 Sep 10. J Biol Chem. 2015. PMID: 26359499 Free PMC article.

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