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A phase I first-in-human study with tefinostat - a monocyte/macrophage targeted histone deacetylase inhibitor - in patients with advanced haematological malignancies.
Ossenkoppele GJ, Lowenberg B, Zachee P, Vey N, Breems D, Van de Loosdrecht AA, Davidson AH, Wells G, Needham L, Bawden L, Toal M, Hooftman L, Debnam PM. Ossenkoppele GJ, et al. Among authors: needham l. Br J Haematol. 2013 Jul;162(2):191-201. doi: 10.1111/bjh.12359. Epub 2013 May 7. Br J Haematol. 2013. PMID: 23647373 Free article. Clinical Trial.
Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.
Needham LA, Davidson AH, Bawden LJ, Belfield A, Bone EA, Brotherton DH, Bryant S, Charlton MH, Clark VL, Davies SJ, Donald A, Day FA, Krige D, Legris V, McDermott J, McGovern Y, Owen J, Patel SR, Pintat S, Testar RJ, Wells GM, Moffat D, Drummond AH. Needham LA, et al. J Pharmacol Exp Ther. 2011 Oct;339(1):132-42. doi: 10.1124/jpet.111.183640. Epub 2011 Jul 21. J Pharmacol Exp Ther. 2011. PMID: 21778281
CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells.
Krige D, Needham LA, Bawden LJ, Flores N, Farmer H, Miles LE, Stone E, Callaghan J, Chandler S, Clark VL, Kirwin-Jones P, Legris V, Owen J, Patel T, Wood S, Box G, Laber D, Odedra R, Wright A, Wood LM, Eccles SA, Bone EA, Ayscough A, Drummond AH. Krige D, et al. Among authors: needham la. Cancer Res. 2008 Aug 15;68(16):6669-79. doi: 10.1158/0008-5472.CAN-07-6627. Cancer Res. 2008. PMID: 18701491 Free article.
Design and synthesis of novel pyrimidine hydroxamic acid inhibitors of histone deacetylases.
Donald AD, Clark VL, Patel S, Day FA, Rowlands MG, Wibata J, Stimson L, Hardcastle A, Eccles SA, McNamara D, Needham LA, Raynaud FI, Aherne W, Moffat DF. Donald AD, et al. Among authors: needham la. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6657-60. doi: 10.1016/j.bmcl.2010.09.016. Epub 2010 Sep 21. Bioorg Med Chem Lett. 2010. PMID: 20884208
POLCAM: instant molecular orientation microscopy for the life sciences.
Bruggeman E, Zhang O, Needham LM, Körbel M, Daly S, Cheetham M, Peters R, Wu T, Klymchenko AS, Davis SJ, Paluch EK, Klenerman D, Lew MD, O'Holleran K, Lee SF. Bruggeman E, et al. Among authors: needham lm. Nat Methods. 2024 Oct;21(10):1873-1883. doi: 10.1038/s41592-024-02382-8. Epub 2024 Oct 7. Nat Methods. 2024. PMID: 39375574 Free PMC article.
Label-free detection and profiling of individual solution-phase molecules.
Needham LM, Saavedra C, Rasch JK, Sole-Barber D, Schweitzer BS, Fairhall AJ, Vollbrecht CH, Wan S, Podorova Y, Bergsten AJ, Mehlenbacher B, Zhang Z, Tenbrake L, Saimi J, Kneely LC, Kirkwood JS, Pfeifer H, Chapman ER, Goldsmith RH. Needham LM, et al. Nature. 2024 May;629(8014):1062-1068. doi: 10.1038/s41586-024-07370-8. Epub 2024 May 8. Nature. 2024. PMID: 38720082
Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
Basu S, Shukron O, Hall D, Parutto P, Ponjavic A, Shah D, Boucher W, Lando D, Zhang W, Reynolds N, Sober LH, Jartseva A, Ragheb R, Ma X, Cramard J, Floyd R, Balmer J, Drury TA, Carr AR, Needham LM, Aubert A, Communie G, Gor K, Steindel M, Morey L, Blanco E, Bartke T, Di Croce L, Berger I, Schaffitzel C, Lee SF, Stevens TJ, Klenerman D, Hendrich BD, Holcman D, Laue ED. Basu S, et al. Among authors: needham lm. Nat Struct Mol Biol. 2024 Feb;31(2):390. doi: 10.1038/s41594-023-01179-1. Nat Struct Mol Biol. 2024. PMID: 38102414 Free PMC article. No abstract available.
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
Basu S, Shukron O, Hall D, Parutto P, Ponjavic A, Shah D, Boucher W, Lando D, Zhang W, Reynolds N, Sober LH, Jartseva A, Ragheb R, Ma X, Cramard J, Floyd R, Balmer J, Drury TA, Carr AR, Needham LM, Aubert A, Communie G, Gor K, Steindel M, Morey L, Blanco E, Bartke T, Di Croce L, Berger I, Schaffitzel C, Lee SF, Stevens TJ, Klenerman D, Hendrich BD, Holcman D, Laue ED. Basu S, et al. Among authors: needham lm. Nat Struct Mol Biol. 2023 Nov;30(11):1628-1639. doi: 10.1038/s41594-023-01095-4. Epub 2023 Sep 28. Nat Struct Mol Biol. 2023. PMID: 37770717 Free PMC article.
481 results