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Page 1
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.
Béguelin W, Popovic R, Teater M, Jiang Y, Bunting KL, Rosen M, Shen H, Yang SN, Wang L, Ezponda T, Martinez-Garcia E, Zhang H, Zheng Y, Verma SK, McCabe MT, Ott HM, Van Aller GS, Kruger RG, Liu Y, McHugh CF, Scott DW, Chung YR, Kelleher N, Shaknovich R, Creasy CL, Gascoyne RD, Wong KK, Cerchietti L, Levine RL, Abdel-Wahab O, Licht JD, Elemento O, Melnick AM. Béguelin W, et al. Among authors: ezponda t. Cancer Cell. 2013 May 13;23(5):677-92. doi: 10.1016/j.ccr.2013.04.011. Cancer Cell. 2013. PMID: 23680150 Free PMC article.
Single-cell transcriptional profile of CD34+ hematopoietic progenitor cells from del(5q) myelodysplastic syndromes and impact of lenalidomide.
Serrano G, Berastegui N, Díaz-Mazkiaran A, García-Olloqui P, Rodriguez-Res C, Huerga-Dominguez S, Ainciburu M, Vilas-Zornoza A, Martin-Uriz PS, Aguirre-Ruiz P, Ullate-Agote A, Ariceta B, Lamo-Espinosa JM, Acha P, Calvete O, Jimenez T, Molero A, Montoro MJ, Díez-Campelo M, Valcarcel D, Solé F, Alfonso-Pierola A, Ochoa I, Prósper F, Ezponda T, Hernaez M. Serrano G, et al. Among authors: ezponda t. Nat Commun. 2024 Jun 20;15(1):5272. doi: 10.1038/s41467-024-49529-x. Nat Commun. 2024. PMID: 38902243 Free PMC article.
Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies.
Oyer JA, Huang X, Zheng Y, Shim J, Ezponda T, Carpenter Z, Allegretta M, Okot-Kotber CI, Patel JP, Melnick A, Levine RL, Ferrando A, Mackerell AD Jr, Kelleher NL, Licht JD, Popovic R. Oyer JA, et al. Among authors: ezponda t. Leukemia. 2014 Jan;28(1):198-201. doi: 10.1038/leu.2013.204. Epub 2013 Jul 4. Leukemia. 2014. PMID: 23823660 Free PMC article. No abstract available.
Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation.
Popovic R, Martinez-Garcia E, Giannopoulou EG, Zhang Q, Zhang Q, Ezponda T, Shah MY, Zheng Y, Will CM, Small EC, Hua Y, Bulic M, Jiang Y, Carrara M, Calogero RA, Kath WL, Kelleher NL, Wang JP, Elemento O, Licht JD. Popovic R, et al. Among authors: ezponda t. PLoS Genet. 2014 Sep 4;10(9):e1004566. doi: 10.1371/journal.pgen.1004566. eCollection 2014 Sep. PLoS Genet. 2014. PMID: 25188243 Free PMC article.
Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape.
Nabet B, Ó Broin P, Reyes JM, Shieh K, Lin CY, Will CM, Popovic R, Ezponda T, Bradner JE, Golden AA, Licht JD. Nabet B, et al. Among authors: ezponda t. Cell Rep. 2015 Aug 25;12(8):1300-13. doi: 10.1016/j.celrep.2015.06.078. Epub 2015 Aug 13. Cell Rep. 2015. PMID: 26279576 Free PMC article.
Increased protein processing gene signature in HDACi-resistant cells predicts response to proteasome inhibitors.
Dupéré-Richer D, Kinal M, Pettersson F, Emond A, Calvo-Vidal MN, Nichol JN, Guilbert C, Plourde D, Klein Oros K, Nielsen TH, Ezponda T, Licht JD, Johnson NA, Assouline S, Cerchietti L, Miller WH Jr, Mann KK. Dupéré-Richer D, et al. Among authors: ezponda t. Leuk Lymphoma. 2017 Jan;58(1):218-221. doi: 10.1080/10428194.2016.1180684. Epub 2016 May 17. Leuk Lymphoma. 2017. PMID: 27185211 No abstract available.
28 results