D'Orazi G - Search Results

1

Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy.

Garufi A, Ricci A, Trisciuoglio D, Iorio E, Carpinelli G, Pistritto G, Cirone M, D'Orazi G. Garufi A, et al. Cell Death Dis. 2013 May 23;4(5):e639. doi: 10.1038/cddis.2013.163. Cell Death Dis. 2013. PMID: 23703384 Free PMC article.

2

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S, Gostissa M, Coen S, Marchetti A, Del Sal G, Piaggio G, Fanciulli M, Appella E, Soddu S. D'Orazi G, et al. Nat Cell Biol. 2002 Jan;4(1):11-9. doi: 10.1038/ncb714. Nat Cell Biol. 2002. PMID: 11780126

3

Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis.

Di Stefano V, Rinaldo C, Sacchi A, Soddu S, D'Orazi G. Di Stefano V, et al. Exp Cell Res. 2004 Feb 15;293(2):311-20. doi: 10.1016/j.yexcr.2003.09.032. Exp Cell Res. 2004. PMID: 14729469

4

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function.

Di Stefano V, Blandino G, Sacchi A, Soddu S, D'Orazi G. Di Stefano V, et al. Oncogene. 2004 Jul 1;23(30):5185-92. doi: 10.1038/sj.onc.1207656. Oncogene. 2004. PMID: 15122315

5

p53 can inhibit cell proliferation through caspase-mediated cleavage of ERK2/MAPK.

Marchetti A, Cecchinelli B, D'Angelo M, D'Orazi G, Crescenzi M, Sacchi A, Soddu S. Marchetti A, et al. Cell Death Differ. 2004 Jun;11(6):596-607. doi: 10.1038/sj.cdd.4401368. Cell Death Differ. 2004. PMID: 15150542

6

HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.

Di Stefano V, Mattiussi M, Sacchi A, D'Orazi G. Di Stefano V, et al. FEBS Lett. 2005 Oct 24;579(25):5473-80. doi: 10.1016/j.febslet.2005.09.008. Epub 2005 Sep 27. FEBS Lett. 2005. PMID: 16212962 Free article.

7

Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.

D'Orazi G, Sciulli MG, Di Stefano V, Riccioni S, Frattini M, Falcioni R, Bertario L, Sacchi A, Patrignani P. D'Orazi G, et al. Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):735-41. doi: 10.1158/1078-0432.CCR-05-1557. Clin Cancer Res. 2006. PMID: 16467083

8

HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway.

Pistritto G, Puca R, Nardinocchi L, Sacchi A, D'Orazi G. Pistritto G, et al. Cell Death Differ. 2007 Oct;14(10):1837-9. doi: 10.1038/sj.cdd.4402186. Epub 2007 Jul 13. Cell Death Differ. 2007. PMID: 17627287 No abstract available.

9

HIPK2 knock-down compromises tumor cell efficiency to repair damaged DNA.

Nardinocchi L, Puca R, Sacchi A, D'Orazi G. Nardinocchi L, et al. Biochem Biophys Res Commun. 2007 Sep 14;361(1):249-55. doi: 10.1016/j.bbrc.2007.07.031. Epub 2007 Jul 17. Biochem Biophys Res Commun. 2007. PMID: 17658469

10

Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells.

Puca R, Nardinocchi L, Pistritto G, D'Orazi G. Puca R, et al. Gynecol Oncol. 2008 Jun;109(3):403-10. doi: 10.1016/j.ygyno.2008.02.018. Epub 2008 Apr 18. Gynecol Oncol. 2008. PMID: 18395248

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