Legler PM - Search Results

1

3-substituted indole inhibitors against Francisella tularensis FabI identified by structure-based virtual screening.

Hu X, Compton JR, Abdulhameed MD, Marchand CL, Robertson KL, Leary DH, Jadhav A, Hershfield JR, Wallqvist A, Friedlander AM, Legler PM. Hu X, et al. Among authors: legler pm. J Med Chem. 2013 Jul 11;56(13):5275-87. doi: 10.1021/jm4001242. Epub 2013 Jul 1. J Med Chem. 2013. PMID: 23815100

2

Introduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogen.

Compton JR, Legler PM, Clingan BV, Olson MA, Millard CB. Compton JR, et al. Among authors: legler pm. Proteins. 2011 Apr;79(4):1048-60. doi: 10.1002/prot.22933. Epub 2011 Jan 5. Proteins. 2011. PMID: 21387408 Free PMC article.

3

Probing the donor and acceptor substrate specificity of the γ-glutamyl transpeptidase.

Hu X, Legler PM, Khavrutskii I, Scorpio A, Compton JR, Robertson KL, Friedlander AM, Wallqvist A. Hu X, et al. Among authors: legler pm. Biochemistry. 2012 Feb 14;51(6):1199-212. doi: 10.1021/bi200987b. Epub 2012 Feb 2. Biochemistry. 2012. PMID: 22257032

4

A role for His-160 in peroxide inhibition of S. cerevisiae S-formylglutathione hydrolase: evidence for an oxidation sensitive motif.

Legler PM, Leary DH, Hervey WJ 4th, Millard CB. Legler PM, et al. Arch Biochem Biophys. 2012 Dec 1;528(1):7-20. doi: 10.1016/j.abb.2012.08.001. Epub 2012 Aug 13. Arch Biochem Biophys. 2012. PMID: 22906720

5

Disruption of the putative vascular leak peptide sequence in the stabilized ricin vaccine candidate RTA1-33/44-198.

Janosi L, Compton JR, Legler PM, Steele KE, Davis JM, Matyas GR, Millard CB. Janosi L, et al. Among authors: legler pm. Toxins (Basel). 2013 Jan 30;5(2):224-48. doi: 10.3390/toxins5020224. Toxins (Basel). 2013. PMID: 23364220 Free PMC article.

6

Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening.

Hu X, Legler PM, Southall N, Maloney DJ, Simeonov A, Jadhav A. Hu X, et al. Among authors: legler pm. J Comput Aided Mol Des. 2014 Jul;28(7):765-78. doi: 10.1007/s10822-014-9758-7. Epub 2014 Jun 24. J Comput Aided Mol Des. 2014. PMID: 24958623 Free PMC article.

7

Development of organophosphate hydrolase activity in a bacterial homolog of human cholinesterase.

Legler PM, Boisvert SM, Compton JR, Millard CB. Legler PM, et al. Front Chem. 2014 Jul 16;2:46. doi: 10.3389/fchem.2014.00046. eCollection 2014. Front Chem. 2014. PMID: 25077141 Free PMC article.

8

Structural and mutational analysis of a monomeric and dimeric form of a single domain antibody with implications for protein misfolding.

George J, Compton JR, Leary DH, Olson MA, Legler PM. George J, et al. Among authors: legler pm. Proteins. 2014 Nov;82(11):3101-16. doi: 10.1002/prot.24671. Epub 2014 Sep 11. Proteins. 2014. PMID: 25136772

9

A reaction path study of the catalysis and inhibition of the Bacillus anthracis CapD γ-glutamyl transpeptidase.

Khavrutskii IV, Legler PM, Friedlander AM, Wallqvist A. Khavrutskii IV, et al. Among authors: legler pm. Biochemistry. 2014 Nov 11;53(44):6954-67. doi: 10.1021/bi500623c. Epub 2014 Oct 31. Biochemistry. 2014. PMID: 25334088

10

A novel Vibrio beta-glucosidase (LamN) that hydrolyzes the algal storage polysaccharide laminarin.

Wang Z, Robertson KL, Liu C, Liu JL, Johnson BJ, Leary DH, Compton JR, Vuddhakul V, Legler PM, Vora GJ. Wang Z, et al. Among authors: legler pm. FEMS Microbiol Ecol. 2015 Aug;91(8):fiv087. doi: 10.1093/femsec/fiv087. Epub 2015 Jul 22. FEMS Microbiol Ecol. 2015. PMID: 26207048

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