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Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor.
Rummel A, Häfner K, Mahrhold S, Darashchonak N, Holt M, Jahn R, Beermann S, Karnath T, Bigalke H, Binz T. Rummel A, et al. Among authors: mahrhold s. J Neurochem. 2009 Sep;110(6):1942-54. doi: 10.1111/j.1471-4159.2009.06298.x. Epub 2009 Jul 23. J Neurochem. 2009. PMID: 19650874 Free article.
23 results