Sexton PM - Search Results

1

Minireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discovery.

Koole C, Savage EE, Christopoulos A, Miller LJ, Sexton PM, Wootten D. Koole C, et al. Among authors: sexton pm. Mol Endocrinol. 2013 Aug;27(8):1234-44. doi: 10.1210/me.2013-1116. Epub 2013 Jul 17. Mol Endocrinol. 2013. PMID: 23864649 Free PMC article. Review.

2

Truncation of the porcine calcitonin receptor cytoplasmic tail inhibits internalization and signal transduction but increases receptor affinity.

Findlay DM, Houssami S, Lin HY, Myers DE, Brady CL, Darcy PK, Ikeda K, Martin TJ, Sexton PM. Findlay DM, et al. Among authors: sexton pm. Mol Endocrinol. 1994 Dec;8(12):1691-700. doi: 10.1210/mend.8.12.7708057. Mol Endocrinol. 1994. PMID: 7708057

3

Novel receptor partners and function of receptor activity-modifying proteins.

Christopoulos A, Christopoulos G, Morfis M, Udawela M, Laburthe M, Couvineau A, Kuwasako K, Tilakaratne N, Sexton PM. Christopoulos A, et al. Among authors: sexton pm. J Biol Chem. 2003 Jan 31;278(5):3293-7. doi: 10.1074/jbc.C200629200. Epub 2002 Nov 21. J Biol Chem. 2003. PMID: 12446722 Free article.

4

RAMPs: 5 years on, where to now?

Morfis M, Christopoulos A, Sexton PM. Morfis M, et al. Among authors: sexton pm. Trends Pharmacol Sci. 2003 Nov;24(11):596-601. doi: 10.1016/j.tips.2003.09.001. Trends Pharmacol Sci. 2003. PMID: 14607083 Review.

5

Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors.

Avlani V, May LT, Sexton PM, Christopoulos A. Avlani V, et al. Among authors: sexton pm. J Pharmacol Exp Ther. 2004 Mar;308(3):1062-72. doi: 10.1124/jpet.103.059840. Epub 2004 Jan 7. J Pharmacol Exp Ther. 2004. PMID: 14711931

6

Allosteric modulation of G protein-coupled receptors.

May LT, Avlani VA, Sexton PM, Christopoulos A. May LT, et al. Among authors: sexton pm. Curr Pharm Des. 2004;10(17):2003-13. doi: 10.2174/1381612043384303. Curr Pharm Des. 2004. PMID: 15279541 Review.

7

Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators.

May LT, Lin Y, Sexton PM, Christopoulos A. May LT, et al. Among authors: sexton pm. J Pharmacol Exp Ther. 2005 Jan;312(1):382-90. doi: 10.1124/jpet.104.073767. Epub 2004 Aug 27. J Pharmacol Exp Ther. 2005. PMID: 15333678

8

Regulation of serotonin 5-HT2C receptors by chronic ligand exposure.

Devlin MG, Smith NJ, Ryan OM, Guida E, Sexton PM, Christopoulos A. Devlin MG, et al. Among authors: sexton pm. Eur J Pharmacol. 2004 Sep 13;498(1-3):59-69. doi: 10.1016/j.ejphar.2004.07.102. Eur J Pharmacol. 2004. PMID: 15363976

9

Amylin receptors: molecular composition and pharmacology.

Hay DL, Christopoulos G, Christopoulos A, Sexton PM. Hay DL, et al. Among authors: sexton pm. Biochem Soc Trans. 2004 Nov;32(Pt 5):865-7. doi: 10.1042/BST0320865. Biochem Soc Trans. 2004. PMID: 15494035 Review.

10

G-protein-coupled receptor allosterism: the promise and the problem(s).

Christopoulos A, May LT, Avlani VA, Sexton PM. Christopoulos A, et al. Among authors: sexton pm. Biochem Soc Trans. 2004 Nov;32(Pt 5):873-7. doi: 10.1042/BST0320873. Biochem Soc Trans. 2004. PMID: 15494038 Review.

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