Gougoutas JZ - Search Results

1

Dihydropyrimidine calcium channel blockers. 2. 3-substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

Atwal KS, Rovnyak GC, Kimball SD, Floyd DM, Moreland S, Swanson BN, Gougoutas JZ, Schwartz J, Smillie KM, Malley MF. Atwal KS, et al. Among authors: gougoutas jz. J Med Chem. 1990 Sep;33(9):2629-35. doi: 10.1021/jm00171a044. J Med Chem. 1990. PMID: 2391701

2

Active conformation of 1,4-dihydropyridine calcium entry blockers. Effect of size of 2-aryl substituent on rotameric equilibria and receptor binding.

Rovnyak G, Andersen N, Gougoutas J, Hedberg A, Kimball SD, Malley M, Moreland S, Porubcan M, Pudzianowski A. Rovnyak G, et al. J Med Chem. 1991 Aug;34(8):2521-4. doi: 10.1021/jm00112a030. J Med Chem. 1991. PMID: 1652021

3

Studies directed toward ascertaining the active conformation of 1,4-dihydropyridine calcium entry blockers.

Rovnyak G, Andersen N, Gougoutas J, Hedberg A, Kimball SD, Malley M, Moreland S, Porubcan M, Pudzianowski A. Rovnyak G, et al. J Med Chem. 1988 May;31(5):936-44. doi: 10.1021/jm00400a008. J Med Chem. 1988. PMID: 2834556

4

Calcium entry blockers and activators: conformational and structural determinants of dihydropyrimidine calcium channel modulators.

Rovnyak GC, Kimball SD, Beyer B, Cucinotta G, DiMarco JD, Gougoutas J, Hedberg A, Malley M, McCarthy JP, Zhang R, et al. Rovnyak GC, et al. J Med Chem. 1995 Jan 6;38(1):119-29. doi: 10.1021/jm00001a017. J Med Chem. 1995. PMID: 7837222

5

Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents.

Rovnyak GC, Atwal KS, Hedberg A, Kimball SD, Moreland S, Gougoutas JZ, O'Reilly BC, Schwartz J, Malley MF. Rovnyak GC, et al. Among authors: gougoutas jz. J Med Chem. 1992 Aug 21;35(17):3254-63. doi: 10.1021/jm00095a023. J Med Chem. 1992. PMID: 1387168

6

Benzazepinone calcium channel blockers. 3. Synthesis and structure-activity studies of 3-alkylbenzazepinones.

Das J, Floyd DM, Kimball SD, Duff KJ, Vu TC, Lago MW, Moquin RV, Lee VG, Gougoutas JZ, Malley MF, et al. Das J, et al. Among authors: gougoutas jz. J Med Chem. 1992 Feb 21;35(4):773-80. doi: 10.1021/jm00082a019. J Med Chem. 1992. PMID: 1542103

7

Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

Atwal KS, Rovnyak GC, Schwartz J, Moreland S, Hedberg A, Gougoutas JZ, Malley MF, Floyd DM. Atwal KS, et al. Among authors: gougoutas jz. J Med Chem. 1990 May;33(5):1510-5. doi: 10.1021/jm00167a035. J Med Chem. 1990. PMID: 2329573

8

Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists.

Stein PD, Floyd DM, Bisaha S, Dickey J, Girotra RN, Gougoutas JZ, Kozlowski M, Lee VG, Liu EC, Malley MF, et al. Stein PD, et al. Among authors: gougoutas jz. J Med Chem. 1995 Apr 14;38(8):1344-54. doi: 10.1021/jm00008a013. J Med Chem. 1995. PMID: 7731020

9

Conformationally constrained calcium channel blockers: novel mimics of 1-benzazepin-2-ones.

Barrish JC, Spergel SH, Moreland S, Grover G, Hedberg SA, Pudzianowski AT, Gougoutas JZ, Malley MF. Barrish JC, et al. Among authors: gougoutas jz. Bioorg Med Chem. 1993 Oct;1(4):309-25. doi: 10.1016/s0968-0896(00)82135-5. Bioorg Med Chem. 1993. PMID: 8081861

10

Urea based CCR3 antagonists employing a tetrahydro-1,3-oxazin-2-one spacer.

Dhar TG, Yang G, Davies P, Malley MF, Gougoutas JZ, Wu DR, Barrish JC, Carter PH. Dhar TG, et al. Among authors: gougoutas jz. Bioorg Med Chem Lett. 2009 Jan 1;19(1):96-9. doi: 10.1016/j.bmcl.2008.11.002. Epub 2008 Nov 6. Bioorg Med Chem Lett. 2009. PMID: 19010676

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