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Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array.
Slieker RC, Bos SD, Goeman JJ, Bovée JV, Talens RP, van der Breggen R, Suchiman HE, Lameijer EW, Putter H, van den Akker EB, Zhang Y, Jukema JW, Slagboom PE, Meulenbelt I, Heijmans BT. Slieker RC, et al. Among authors: van den akker eb, van der breggen r. Epigenetics Chromatin. 2013 Aug 6;6(1):26. doi: 10.1186/1756-8935-6-26. Epigenetics Chromatin. 2013. PMID: 23919675 Free PMC article.
Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis.
Meulenbelt I, Min JL, Bos S, Riyazi N, Houwing-Duistermaat JJ, van der Wijk HJ, Kroon HM, Nakajima M, Ikegawa S, Uitterlinden AG, van Meurs JB, van der Deure WM, Visser TJ, Seymour AB, Lakenberg N, van der Breggen R, Kremer D, van Duijn CM, Kloppenburg M, Loughlin J, Slagboom PE. Meulenbelt I, et al. Among authors: van duijn cm, van der wijk hj, van meurs jb, van der breggen r, van der deure wm. Hum Mol Genet. 2008 Jun 15;17(12):1867-75. doi: 10.1093/hmg/ddn082. Epub 2008 Mar 11. Hum Mol Genet. 2008. PMID: 18334578
Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations.
Meulenbelt I, Chapman K, Dieguez-Gonzalez R, Shi D, Tsezou A, Dai J, Malizos KN, Kloppenburg M, Carr A, Nakajima M, van der Breggen R, Lakenberg N, Gomez-Reino JJ, Jiang Q, Ikegawa S, Gonzalez A, Loughlin J, Slagboom EP. Meulenbelt I, et al. Among authors: van der breggen r. Hum Mol Genet. 2009 Apr 15;18(8):1518-23. doi: 10.1093/hmg/ddp053. Epub 2009 Jan 30. Hum Mol Genet. 2009. PMID: 19181678
Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility.
Meulenbelt I, Bos SD, Chapman K, van der Breggen R, Houwing-Duistermaat JJ, Kremer D, Kloppenburg M, Carr A, Tsezou A, González A, Loughlin J, Slagboom PE. Meulenbelt I, et al. Among authors: van der breggen r. Ann Rheum Dis. 2011 Jan;70(1):164-7. doi: 10.1136/ard.2010.133660. Epub 2010 Aug 19. Ann Rheum Dis. 2011. PMID: 20724312
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity.
Beekman M, Nederstigt C, Suchiman HE, Kremer D, van der Breggen R, Lakenberg N, Alemayehu WG, de Craen AJ, Westendorp RG, Boomsma DI, de Geus EJ, Houwing-Duistermaat JJ, Heijmans BT, Slagboom PE. Beekman M, et al. Among authors: van der breggen r. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18046-9. doi: 10.1073/pnas.1003540107. Epub 2010 Oct 4. Proc Natl Acad Sci U S A. 2010. PMID: 20921414 Free PMC article.
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HE, Lakenberg N, van den Akker EB, Passtoors WM, Tiemeier H, van Heemst D, de Craen AJ, Rivadeneira F, de Geus EJ, Perola M, van der Ouderaa FJ, Gunn DA, Boomsma DI, Uitterlinden AG, Christensen K, van Duijn CM, Heijmans BT, Houwing-Duistermaat JJ, Westendorp RG, Slagboom PE. Deelen J, et al. Among authors: van den akker eb, van duijn cm, van heemst d, van der ouderaa fj, van der breggen r. Aging Cell. 2011 Aug;10(4):686-98. doi: 10.1111/j.1474-9726.2011.00705.x. Epub 2011 May 6. Aging Cell. 2011. PMID: 21418511 Free PMC article.
Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues.
Bos SD, Bovée JV, Duijnisveld BJ, Raine EV, van Dalen WJ, Ramos YF, van der Breggen R, Nelissen RG, Slagboom PE, Loughlin J, Meulenbelt I. Bos SD, et al. Among authors: van der breggen r, van dalen wj. Ann Rheum Dis. 2012 Jul;71(7):1254-8. doi: 10.1136/annrheumdis-2011-200981. Epub 2012 Apr 4. Ann Rheum Dis. 2012. PMID: 22492780
Gene expression analysis of mTOR pathway: association with human longevity.
Passtoors WM, Beekman M, Deelen J, van der Breggen R, Maier AB, Guigas B, Derhovanessian E, van Heemst D, de Craen AJ, Gunn DA, Pawelec G, Slagboom PE. Passtoors WM, et al. Among authors: van heemst d, van der breggen r. Aging Cell. 2013 Feb;12(1):24-31. doi: 10.1111/acel.12015. Epub 2012 Nov 23. Aging Cell. 2013. PMID: 23061800 Free article.
Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs.
Ye K, Beekman M, Lameijer EW, Zhang Y, Moed MH, van den Akker EB, Deelen J, Houwing-Duistermaat JJ, Kremer D, Anvar SY, Laros JF, Jones D, Raine K, Blackburne B, Potluri S, Long Q, Guryev V, van der Breggen R, Westendorp RG, 't Hoen PA, den Dunnen J, van Ommen GJ, Willemsen G, Pitts SJ, Cox DR, Ning Z, Boomsma DI, Slagboom PE. Ye K, et al. Among authors: van den akker eb, van ommen gj, van der breggen r. Twin Res Hum Genet. 2013 Dec;16(6):1026-32. doi: 10.1017/thg.2013.73. Epub 2013 Nov 4. Twin Res Hum Genet. 2013. PMID: 24182360
58 results