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The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells.
Raczkowski F, Ritter J, Heesch K, Schumacher V, Guralnik A, Höcker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrücker HW, Huber M. Raczkowski F, et al. Among authors: huber m. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15019-24. doi: 10.1073/pnas.1309378110. Epub 2013 Aug 26. Proc Natl Acad Sci U S A. 2013. PMID: 23980171 Free PMC article.
IL-27 inhibits the development of regulatory T cells via STAT3.
Huber M, Steinwald V, Guralnik A, Brüstle A, Kleemann P, Rosenplänter C, Decker T, Lohoff M. Huber M, et al. Int Immunol. 2008 Feb;20(2):223-34. doi: 10.1093/intimm/dxm139. Epub 2007 Dec 21. Int Immunol. 2008. PMID: 18156621
Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation.
Bollig N, Brüstle A, Kellner K, Ackermann W, Abass E, Raifer H, Camara B, Brendel C, Giel G, Bothur E, Huber M, Paul C, Elli A, Kroczek RA, Nurieva R, Dong C, Jacob R, Mak TW, Lohoff M. Bollig N, et al. Among authors: huber m. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8664-9. doi: 10.1073/pnas.1205834109. Epub 2012 May 2. Proc Natl Acad Sci U S A. 2012. PMID: 22552227 Free PMC article.
Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22.
Raifer H, Mahiny AJ, Bollig N, Petermann F, Hellhund A, Kellner K, Guralnik A, Reinhard K, Bothur E, Huber M, Bauer S, Löhning M, Kiss EA, Ganal SC, Diefenbach A, Korn T, Lohoff M. Raifer H, et al. Among authors: huber m. Eur J Immunol. 2012 Dec;42(12):3189-201. doi: 10.1002/eji.201142155. Epub 2012 Oct 17. Eur J Immunol. 2012. PMID: 22961652 Free article.
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis.
Huber M, Heink S, Pagenstecher A, Reinhard K, Ritter J, Visekruna A, Guralnik A, Bollig N, Jeltsch K, Heinemann C, Wittmann E, Buch T, Prazeres da Costa O, Brüstle A, Brenner D, Mak TW, Mittrücker HW, Tackenberg B, Kamradt T, Lohoff M. Huber M, et al. J Clin Invest. 2013 Jan;123(1):247-60. doi: 10.1172/JCI63681. Epub 2012 Dec 10. J Clin Invest. 2013. PMID: 23221338 Free PMC article.
Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation.
Visekruna A, Ritter J, Scholz T, Campos L, Guralnik A, Poncette L, Raifer H, Hagner S, Garn H, Staudt V, Bopp T, Reuter S, Taube C, Loser K, Huber M. Visekruna A, et al. Among authors: huber m. Eur J Immunol. 2013 Mar;43(3):606-18. doi: 10.1002/eji.201242825. Epub 2013 Jan 31. Eur J Immunol. 2013. PMID: 23254356 Free article.
IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV.
Grusdat M, McIlwain DR, Xu HC, Pozdeev VI, Knievel J, Crome SQ, Robert-Tissot C, Dress RJ, Pandyra AA, Speiser DE, Lang E, Maney SK, Elford AR, Hamilton SR, Scheu S, Pfeffer K, Bode J, Mittrücker HW, Lohoff M, Huber M, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA. Grusdat M, et al. Among authors: huber m. Cell Death Differ. 2014 Jul;21(7):1050-60. doi: 10.1038/cdd.2014.19. Epub 2014 Feb 14. Cell Death Differ. 2014. PMID: 24531538 Free PMC article.
2,123 results