Wood BM - Search Results

1

Discovery of new enzymes and metabolic pathways by using structure and genome context.

Zhao S, Kumar R, Sakai A, Vetting MW, Wood BM, Brown S, Bonanno JB, Hillerich BS, Seidel RD, Babbitt PC, Almo SC, Sweedler JV, Gerlt JA, Cronan JE, Jacobson MP. Zhao S, et al. Among authors: wood bm. Nature. 2013 Oct 31;502(7473):698-702. doi: 10.1038/nature12576. Epub 2013 Sep 22. Nature. 2013. PMID: 24056934 Free PMC article.

2

Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine.

Kumar R, Zhao S, Vetting MW, Wood BM, Sakai A, Cho K, Solbiati J, Almo SC, Sweedler JV, Jacobson MP, Gerlt JA, Cronan JE. Kumar R, et al. Among authors: wood bm. mBio. 2014 Feb 11;5(1):e00933-13. doi: 10.1128/mBio.00933-13. mBio. 2014. PMID: 24520058 Free PMC article.

3

A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis.

Erb TJ, Evans BS, Cho K, Warlick BP, Sriram J, Wood BM, Imker HJ, Sweedler JV, Tabita FR, Gerlt JA. Erb TJ, et al. Among authors: wood bm. Nat Chem Biol. 2012 Nov;8(11):926-32. doi: 10.1038/nchembio.1087. Epub 2012 Oct 7. Nat Chem Biol. 2012. PMID: 23042035 Free PMC article.

4

Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme.

Desai BJ, Wood BM, Fedorov AA, Fedorov EV, Goryanova B, Amyes TL, Richard JP, Almo SC, Gerlt JA. Desai BJ, et al. Among authors: wood bm. Biochemistry. 2012 Oct 30;51(43):8665-78. doi: 10.1021/bi301188k. Epub 2012 Oct 17. Biochemistry. 2012. PMID: 23030629 Free PMC article.

5

Orotidine 5'-monophosphate decarboxylase: transition state stabilization from remote protein-phosphodianion interactions.

Amyes TL, Ming SA, Goldman LM, Wood BM, Desai BJ, Gerlt JA, Richard JP. Amyes TL, et al. Among authors: wood bm. Biochemistry. 2012 Jun 12;51(23):4630-2. doi: 10.1021/bi300585e. Epub 2012 May 31. Biochemistry. 2012. PMID: 22620855 Free PMC article.

6

Integration of untargeted metabolomics with transcriptomics reveals active metabolic pathways.

Cho K, Evans BS, Wood BM, Kumar R, Erb TJ, Warlick BP, Gerlt JA, Sweedler JV. Cho K, et al. Among authors: wood bm. Metabolomics. 2014 Sep 3;2014(August):503-17. doi: 10.1007/s11306-014-0713-3. Metabolomics. 2014. PMID: 25705145 Free PMC article.

7

An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms.

Toth K, Amyes TL, Wood BM, Chan KK, Gerlt JA, Richard JP. Toth K, et al. Among authors: wood bm. Biochemistry. 2009 Aug 25;48(33):8006-13. doi: 10.1021/bi901064k. Biochemistry. 2009. PMID: 19618917 Free PMC article.

8

Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP.

Amyes TL, Wood BM, Chan K, Gerlt JA, Richard JP. Amyes TL, et al. Among authors: wood bm. J Am Chem Soc. 2008 Feb 6;130(5):1574-5. doi: 10.1021/ja710384t. Epub 2008 Jan 11. J Am Chem Soc. 2008. PMID: 18186641 Free PMC article.

9

Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate.

Toth K, Amyes TL, Wood BM, Chan K, Gerlt JA, Richard JP. Toth K, et al. Among authors: wood bm. J Am Chem Soc. 2010 May 26;132(20):7018-24. doi: 10.1021/ja102408k. J Am Chem Soc. 2010. PMID: 20441167 Free PMC article.

10

Proton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituent.

Tsang WY, Wood BM, Wong FM, Wu W, Gerlt JA, Amyes TL, Richard JP. Tsang WY, et al. Among authors: wood bm. J Am Chem Soc. 2012 Sep 5;134(35):14580-94. doi: 10.1021/ja3058474. Epub 2012 Aug 21. J Am Chem Soc. 2012. PMID: 22812629 Free PMC article.

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