Rader DJ - Search Results

1

Biodistribution of AAV8 vectors expressing human low-density lipoprotein receptor in a mouse model of homozygous familial hypercholesterolemia.

Chen SJ, Sanmiguel J, Lock M, McMenamin D, Draper C, Limberis MP, Kassim SH, Somanathan S, Bell P, Johnston JC, Rader DJ, Wilson JM. Chen SJ, et al. Among authors: rader dj. Hum Gene Ther Clin Dev. 2013 Dec;24(4):154-60. doi: 10.1089/humc.2013.082. Epub 2013 Nov 9. Hum Gene Ther Clin Dev. 2013. PMID: 24070336 Free PMC article.

2

A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia.

Grossman M, Rader DJ, Muller DW, Kolansky DM, Kozarsky K, Clark BJ 3rd, Stein EA, Lupien PJ, Brewer HB Jr, Raper SE, et al. Grossman M, et al. Among authors: rader dj. Nat Med. 1995 Nov;1(11):1148-54. doi: 10.1038/nm1195-1148. Nat Med. 1995. PMID: 7584986 Clinical Trial.

3

Safety and feasibility of liver-directed ex vivo gene therapy for homozygous familial hypercholesterolemia.

Raper SE, Grossman M, Rader DJ, Thoene JG, Clark BJ 3rd, Kolansky DM, Muller DW, Wilson JM. Raper SE, et al. Among authors: rader dj. Ann Surg. 1996 Feb;223(2):116-26. doi: 10.1097/00000658-199602000-00002. Ann Surg. 1996. PMID: 8597504 Free PMC article. Clinical Trial.

4

Hepatic expression of apolipoprotein E inhibits progression of atherosclerosis without reducing cholesterol levels in LDL receptor-deficient mice.

Tsukamoto K, Tangirala RK, Chun S, Usher D, Puré E, Rader DJ. Tsukamoto K, et al. Among authors: rader dj. Mol Ther. 2000 Feb;1(2):189-94. doi: 10.1006/mthe.2000.0028. Mol Ther. 2000. PMID: 10933930 Free article.

5

Prolonged correction of hyperlipidemia in mice with familial hypercholesterolemia using an adeno-associated viral vector expressing very-low-density lipoprotein receptor.

Chen SJ, Rader DJ, Tazelaar J, Kawashiri M, Gao G, Wilson JM. Chen SJ, et al. Among authors: rader dj. Mol Ther. 2000 Sep;2(3):256-61. doi: 10.1006/mthe.2000.0122. Mol Ther. 2000. PMID: 10985956 Free article.

6

Phenotypic correction of lipid storage and growth arrest in wolman disease fibroblasts by gene transfer of lysosomal acid lipase.

Tietge UJ, Sun G, Czarnecki S, Yu Q, Lohse P, Du H, Grabowski GA, Glick JM, Rader DJ. Tietge UJ, et al. Among authors: rader dj. Hum Gene Ther. 2001 Feb 10;12(3):279-89. doi: 10.1089/10430340150218413. Hum Gene Ther. 2001. PMID: 11177564

7

Gene therapy for familial hypercholesterolemia.

Rader DJ. Rader DJ. Nutr Metab Cardiovasc Dis. 2001 Oct;11 Suppl 5:40-4. Nutr Metab Cardiovasc Dis. 2001. PMID: 12063775 Review.

8

Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia.

Zhao L, Cuff CA, Moss E, Wille U, Cyrus T, Klein EA, Praticò D, Rader DJ, Hunter CA, Puré E, Funk CD. Zhao L, et al. Among authors: rader dj. J Biol Chem. 2002 Sep 20;277(38):35350-6. doi: 10.1074/jbc.M205738200. Epub 2002 Jul 16. J Biol Chem. 2002. PMID: 12122008 Free article.

9

Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia.

Lebherz C, Gao G, Louboutin JP, Millar J, Rader D, Wilson JM. Lebherz C, et al. J Gene Med. 2004 Jun;6(6):663-72. doi: 10.1002/jgm.554. J Gene Med. 2004. PMID: 15170737

10

Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production.

Millar JS, Maugeais C, Ikewaki K, Kolansky DM, Barrett PH, Budreck EC, Boston RC, Tada N, Mochizuki S, Defesche JC, Wilson JM, Rader DJ. Millar JS, et al. Among authors: rader dj. Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):560-5. doi: 10.1161/01.ATV.0000155323.18856.a2. Epub 2005 Jan 6. Arterioscler Thromb Vasc Biol. 2005. PMID: 15637307

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