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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.
Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, Chen ZP, O'Neill HM, Ford RJ, Palanivel R, O'Brien M, Hardie DG, Macaulay SL, Schertzer JD, Dyck JR, van Denderen BJ, Kemp BE, Steinberg GR. Fullerton MD, et al. Among authors: pulinilkunnil t. Nat Med. 2013 Dec;19(12):1649-54. doi: 10.1038/nm.3372. Epub 2013 Nov 3. Nat Med. 2013. PMID: 24185692 Free PMC article.
AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice.
O'Neill HM, Lally JS, Galic S, Thomas M, Azizi PD, Fullerton MD, Smith BK, Pulinilkunnil T, Chen Z, Samaan MC, Jorgensen SB, Dyck JR, Holloway GP, Hawke TJ, van Denderen BJ, Kemp BE, Steinberg GR. O'Neill HM, et al. Among authors: pulinilkunnil t. Diabetologia. 2014 Aug;57(8):1693-702. doi: 10.1007/s00125-014-3273-1. Epub 2014 Jun 10. Diabetologia. 2014. PMID: 24913514
Myocardial triacylglycerol metabolism.
Kienesberger PC, Pulinilkunnil T, Nagendran J, Dyck JR. Kienesberger PC, et al. Among authors: pulinilkunnil t. J Mol Cell Cardiol. 2013 Feb;55:101-10. doi: 10.1016/j.yjmcc.2012.06.018. Epub 2012 Jul 10. J Mol Cell Cardiol. 2013. PMID: 22789525 Review.
80 results