Lamb RF - Search Results

1

Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts.

Groenewoud MJ, Goorden SM, Kassies J, Pellis-van Berkel W, Lamb RF, Elgersma Y, Zwartkruis FJ. Groenewoud MJ, et al. Among authors: lamb rf. PLoS One. 2013 Nov 26;8(11):e81649. doi: 10.1371/journal.pone.0081649. eCollection 2013. PLoS One. 2013. PMID: 24303063 Free PMC article.

2

Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase.

Yan L, Findlay GM, Jones R, Procter J, Cao Y, Lamb RF. Yan L, et al. Among authors: lamb rf. J Biol Chem. 2006 Jul 21;281(29):19793-7. doi: 10.1074/jbc.C600028200. Epub 2006 May 25. J Biol Chem. 2006. PMID: 16728407 Free article.

3

T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming.

Yang K, Shrestha S, Zeng H, Karmaus PW, Neale G, Vogel P, Guertin DA, Lamb RF, Chi H. Yang K, et al. Among authors: lamb rf. Immunity. 2013 Dec 12;39(6):1043-56. doi: 10.1016/j.immuni.2013.09.015. Epub 2013 Dec 5. Immunity. 2013. PMID: 24315998 Free PMC article.

4

Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR.

Xiao B, Zuo D, Hirukawa A, Cardiff RD, Lamb R, Sonenberg N, Muller WJ. Xiao B, et al. Cell Rep. 2020 Apr 28;31(4):107571. doi: 10.1016/j.celrep.2020.107571. Cell Rep. 2020. PMID: 32348753 Free PMC article.

5

TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?

Findlay GM, Harrington LS, Lamb RF. Findlay GM, et al. Among authors: lamb rf. Curr Opin Genet Dev. 2005 Feb;15(1):69-76. doi: 10.1016/j.gde.2004.11.002. Curr Opin Genet Dev. 2005. PMID: 15661536

6

A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling.

Findlay GM, Yan L, Procter J, Mieulet V, Lamb RF. Findlay GM, et al. Among authors: lamb rf. Biochem J. 2007 Apr 1;403(1):13-20. doi: 10.1042/BJ20061881. Biochem J. 2007. PMID: 17253963 Free PMC article.

7

PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.

Yan L, Mieulet V, Burgess D, Findlay GM, Sully K, Procter J, Goris J, Janssens V, Morrice NA, Lamb RF. Yan L, et al. Among authors: lamb rf. Mol Cell. 2010 Mar 12;37(5):633-42. doi: 10.1016/j.molcel.2010.01.031. Mol Cell. 2010. PMID: 20227368 Free article.

8

Restraining PI3K: mTOR signalling goes back to the membrane.

Harrington LS, Findlay GM, Lamb RF. Harrington LS, et al. Among authors: lamb rf. Trends Biochem Sci. 2005 Jan;30(1):35-42. doi: 10.1016/j.tibs.2004.11.003. Trends Biochem Sci. 2005. PMID: 15653324 Review.

9

mTORC2 is the hydrophobic motif kinase for SGK1.

Yan L, Mieulet V, Lamb RF. Yan L, et al. Among authors: lamb rf. Biochem J. 2008 Dec 15;416(3):e19-21. doi: 10.1042/BJ20082202. Biochem J. 2008. PMID: 19025518

10

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent.

Jaeschke A, Hartkamp J, Saitoh M, Roworth W, Nobukuni T, Hodges A, Sampson J, Thomas G, Lamb R. Jaeschke A, et al. J Cell Biol. 2002 Oct 28;159(2):217-24. doi: 10.1083/jcb.jcb.200206108. Epub 2002 Oct 28. J Cell Biol. 2002. PMID: 12403809 Free PMC article.

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