McDonough JH - Search Results

1

Stereoselective anticonvulsant and pharmacokinetic analysis of valnoctamide, a CNS-active derivative of valproic acid with low teratogenic potential.

Shekh-Ahmad T, Hen N, Yagen B, McDonough JH, Finnell RH, Wlodarczyk BJ, Bialer M. Shekh-Ahmad T, et al. Among authors: mcdonough jh. Epilepsia. 2014 Feb;55(2):353-61. doi: 10.1111/epi.12480. Epub 2013 Dec 6. Epilepsia. 2014. PMID: 24313671 Free PMC article.

2

Comparative efficacy of valnoctamide and sec-butylpropylacetamide (SPD) in terminating nerve agent-induced seizures in pediatric rats.

Haines KM, Matson LM, Dunn EN, Ardinger CE, Lee-Stubbs R, Bibi D, McDonough JH, Bialer M. Haines KM, et al. Among authors: mcdonough jh. Epilepsia. 2019 Feb;60(2):315-321. doi: 10.1111/epi.14630. Epub 2019 Jan 7. Epilepsia. 2019. PMID: 30615805 Free PMC article.

3

A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.

White HS, Alex AB, Pollock A, Hen N, Shekh-Ahmad T, Wilcox KS, McDonough JH, Stables JP, Kaufmann D, Yagen B, Bialer M. White HS, et al. Among authors: mcdonough jh. Epilepsia. 2012 Jan;53(1):134-46. doi: 10.1111/j.1528-1167.2011.03338.x. Epub 2011 Dec 9. Epilepsia. 2012. PMID: 22150444 Free PMC article.

4

Stereoselective pharmacodynamic and pharmacokinetic analysis of sec-Butylpropylacetamide (SPD), a new CNS-active derivative of valproic acid with unique activity against status epilepticus.

Hen N, Shekh-Ahmad T, Yagen B, McDonough JH, Finnell RH, Wlodarczyk B, Bialer M. Hen N, et al. Among authors: mcdonough jh. J Med Chem. 2013 Aug 22;56(16):6467-77. doi: 10.1021/jm4007565. Epub 2013 Aug 7. J Med Chem. 2013. PMID: 23879329

5

Valnoctamide and sec-butyl-propylacetamide (SPD) for acute seizures and status epilepticus.

Shekh-Ahmad T, Hen N, McDonough JH, Yagen B, Bialer M. Shekh-Ahmad T, et al. Among authors: mcdonough jh. Epilepsia. 2013 Sep;54 Suppl 6(Suppl 6):99-102. doi: 10.1111/epi.12290. Epilepsia. 2013. PMID: 24001086 Free PMC article.

6

Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid.

Shekh-Ahmad T, Mawasi H, McDonough JH, Finnell RH, Wlodarczyk BJ, Yavin E, Bialer M. Shekh-Ahmad T, et al. Among authors: mcdonough jh. Epilepsia. 2014 Dec;55(12):1944-52. doi: 10.1111/epi.12857. Epub 2014 Nov 29. Epilepsia. 2014. PMID: 25442425 Free article. Clinical Trial.

7

The potential of sec-butylpropylacetamide (SPD) and valnoctamide and their individual stereoisomers in status epilepticus.

Shekh-Ahmad T, Mawasi H, McDonough JH, Yagen B, Bialer M. Shekh-Ahmad T, et al. Among authors: mcdonough jh. Epilepsy Behav. 2015 Aug;49:298-302. doi: 10.1016/j.yebeh.2015.04.012. Epub 2015 May 13. Epilepsy Behav. 2015. PMID: 25979572 Review.

8

The synthetic neuroactive steroid SGE-516 reduces status epilepticus and neuronal cell death in a rat model of soman intoxication.

Althaus AL, McCarren HS, Alqazzaz A, Jackson C, McDonough JH, Smith CD, Hoffman E, Hammond RS, Robichaud AJ, Doherty JJ. Althaus AL, et al. Among authors: mcdonough jh. Epilepsy Behav. 2017 Mar;68:22-30. doi: 10.1016/j.yebeh.2016.12.024. Epub 2017 Jan 18. Epilepsy Behav. 2017. PMID: 28109985 Free article.

9

Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats.

Matson L, Dunn E, Haines K, Miller-Smith S, Lee-Stubbs R, Whitten K, Ardinger C, McCarren H, McDonough J. Matson L, et al. Neurotoxicology. 2019 Sep;74:203-208. doi: 10.1016/j.neuro.2019.07.006. Epub 2019 Jul 27. Neurotoxicology. 2019. PMID: 31362008 Free PMC article.

10

Dexmedetomidine stops benzodiazepine-refractory nerve agent-induced status epilepticus.

McCarren HS, Arbutus JA, Ardinger C, Dunn EN, Jackson CE, McDonough JH. McCarren HS, et al. Among authors: mcdonough jh. Epilepsy Res. 2018 Mar;141:1-12. doi: 10.1016/j.eplepsyres.2018.01.010. Epub 2018 Jan 31. Epilepsy Res. 2018. PMID: 29414381 Free PMC article.

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