Mandlekar S - Search Results

1

Expression and characterization of cynomolgus monkey cytochrome CYP3A4 in a novel human embryonic kidney cell-based mammalian system.

Selvakumar S, Bhutani P, Ghosh K, Krishnamurthy P, Kallipatti S, Selvam S, Ramarao M, Mandlekar S, Sinz MW, Rodrigues AD, Subramanian M. Selvakumar S, et al. Among authors: mandlekar s. Drug Metab Dispos. 2014 Mar;42(3):369-76. doi: 10.1124/dmd.113.055491. Epub 2013 Dec 13. Drug Metab Dispos. 2014. PMID: 24335510

2

Characterization of recombinantly expressed rat and monkey intestinal alkaline phosphatases: in vitro studies and in vivo correlations.

Subramanian M, Paruchury S, Singh Gautam S, Pratap Singh S, Arla R, Pahwa S, Jana S, Katnapally P, Yoganand V, Lakshmaiah B, Mazumder Tagore D, Ghosh K, Marathe P, Mandlekar S. Subramanian M, et al. Among authors: mandlekar s. Drug Metab Dispos. 2013 Jul;41(7):1425-32. doi: 10.1124/dmd.113.051987. Epub 2013 Apr 30. Drug Metab Dispos. 2013. PMID: 23633529

3

Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro.

Zhang Y, Han YH, Putluru SP, Matta MK, Kole P, Mandlekar S, Furlong MT, Liu T, Iyer RA, Marathe P, Yang Z, Lai Y, Rodrigues AD. Zhang Y, et al. Among authors: mandlekar s. Drug Metab Dispos. 2016 Mar;44(3):320-8. doi: 10.1124/dmd.115.066944. Epub 2015 Dec 29. Drug Metab Dispos. 2016. PMID: 26714763

4

A Novel Liquid Chromatography Tandem Mass Spectrometry Method for the Estimation of Bilirubin Glucuronides and its Application to In Vitro Enzyme Assays.

Putluru SP, Matta MK, Ahire D, Subramanian M, Sinz M, Mandlekar S. Putluru SP, et al. Among authors: mandlekar s. Drug Metab Lett. 2017;10(4):264-269. doi: 10.2174/1872312810666161124143522. Drug Metab Lett. 2017. PMID: 27908259

5

Metabolite Identification, Reaction Phenotyping, and Retrospective Drug-Drug Interaction Predictions of 17-Deacetylnorgestimate, the Active Component of the Oral Contraceptive Norgestimate.

Ahire D, Sinha S, Brock B, Iyer R, Mandlekar S, Subramanian M. Ahire D, et al. Among authors: mandlekar s. Drug Metab Dispos. 2017 Jun;45(6):676-685. doi: 10.1124/dmd.116.073940. Epub 2017 Mar 10. Drug Metab Dispos. 2017. PMID: 28283499

6

A simplified protocol employing elacridar in rodents: a screening model in drug discovery to assess P-gp mediated efflux at the blood brain barrier.

Kallem R, Kulkarni CP, Patel D, Thakur M, Sinz M, Singh SP, Mahammad SS, Mandlekar S. Kallem R, et al. Among authors: mandlekar s. Drug Metab Lett. 2012 Jun 1;6(2):134-44. Drug Metab Lett. 2012. PMID: 23061481

7

Role of hepatic blood flow and metabolism in the pharmacokinetics of ten drugs in lean, aged and obese rats.

Subramanian M, Kurawattimath V, Pocha K, Freeden C, Rao I, Mariappan TT, Marathe PH, Vikramadithyan RK, Abraham P, Kulkarni CP, Katnapally P, Nutakki R, Paruchury S, Bhutani P, Mandlekar S. Subramanian M, et al. Among authors: mandlekar s. Xenobiotica. 2014 Dec;44(12):1108-16. doi: 10.3109/00498254.2014.932470. Epub 2014 Jun 20. Xenobiotica. 2014. PMID: 24947446

8

Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models.

Holenarsipur VK, Gaud N, Sinha J, Sivaprasad S, Bhutani P, Subramanian M, Singh SP, Arla R, Paruchury S, Sharma T, Marathe P, Mandlekar S. Holenarsipur VK, et al. Among authors: mandlekar s. Biopharm Drug Dispos. 2015 Sep;36(6):385-397. doi: 10.1002/bdd.1950. Epub 2015 May 4. Biopharm Drug Dispos. 2015. PMID: 25832562

9

Absolute quantification of imipramine and its metabolites in vivo utilizing calibrators from radiolabeled in vitro incubations.

Bhutani P, Shah D, Varkhede N, Mandlekar S, Chacko S, Subramanian M. Bhutani P, et al. Among authors: mandlekar s. Bioanalysis. 2016 Feb;8(4):297-309. doi: 10.4155/bio.15.259. Epub 2016 Feb 5. Bioanalysis. 2016. PMID: 26847656

10

A systematic evaluation of solubility enhancing excipients to enable the generation of permeability data for poorly soluble compounds in Caco-2 model.

Shah D, Paruchury S, Matta M, Chowan G, Subramanian M, Saxena A, Soars MG, Herbst J, Haskell R, Marathe P, Mandlekar S. Shah D, et al. Among authors: mandlekar s. Drug Metab Lett. 2014;8(2):109-18. doi: 10.2174/1872312808666141127113055. Drug Metab Lett. 2014. PMID: 25429513

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