Rodrigues AD - Search Results

1

Expression and characterization of cynomolgus monkey cytochrome CYP3A4 in a novel human embryonic kidney cell-based mammalian system.

Selvakumar S, Bhutani P, Ghosh K, Krishnamurthy P, Kallipatti S, Selvam S, Ramarao M, Mandlekar S, Sinz MW, Rodrigues AD, Subramanian M. Selvakumar S, et al. Among authors: rodrigues ad. Drug Metab Dispos. 2014 Mar;42(3):369-76. doi: 10.1124/dmd.113.055491. Epub 2013 Dec 13. Drug Metab Dispos. 2014. PMID: 24335510

2

Cytochrome P450 reaction-phenotyping: an industrial perspective.

Zhang H, Davis CD, Sinz MW, Rodrigues AD. Zhang H, et al. Among authors: rodrigues ad. Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):667-87. doi: 10.1517/17425255.3.5.667. Expert Opin Drug Metab Toxicol. 2007. PMID: 17916054 Review.

3

Cynomolgus monkey as a potential model to assess drug interactions involving hepatic organic anion transporting polypeptides: in vitro, in vivo, and in vitro-to-in vivo extrapolation.

Shen H, Yang Z, Mintier G, Han YH, Chen C, Balimane P, Jemal M, Zhao W, Zhang R, Kallipatti S, Selvam S, Sukrutharaj S, Krishnamurthy P, Marathe P, Rodrigues AD. Shen H, et al. Among authors: rodrigues ad. J Pharmacol Exp Ther. 2013 Mar;344(3):673-85. doi: 10.1124/jpet.112.200691. Epub 2013 Jan 7. J Pharmacol Exp Ther. 2013. PMID: 23297161

4

Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation.

Shen H, Liu T, Jiang H, Titsch C, Taylor K, Kandoussi H, Qiu X, Chen C, Sukrutharaj S, Kuit K, Mintier G, Krishnamurthy P, Fancher RM, Zeng J, Rodrigues AD, Marathe P, Lai Y. Shen H, et al. Among authors: rodrigues ad. Drug Metab Dispos. 2016 Feb;44(2):238-49. doi: 10.1124/dmd.115.066852. Epub 2015 Nov 25. Drug Metab Dispos. 2016. PMID: 26608080

5

Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human.

Haarhoff ZE, Kramer MA, Zvyaga TA, Zhang J, Bhutani P, Subramanian M, Rodrigues AD. Haarhoff ZE, et al. Among authors: rodrigues ad. Xenobiotica. 2017 Jun;47(6):470-478. doi: 10.1080/00498254.2016.1203042. Epub 2016 Aug 8. Xenobiotica. 2017. PMID: 27498589

6

Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis.

Yao M, Zhu M, Sinz MW, Zhang H, Humphreys WG, Rodrigues AD, Dai R. Yao M, et al. Among authors: rodrigues ad. J Pharm Biomed Anal. 2007 May 9;44(1):211-23. doi: 10.1016/j.jpba.2007.02.034. Epub 2007 Mar 3. J Pharm Biomed Anal. 2007. PMID: 17418993

7

Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro.

Zhang Y, Han YH, Putluru SP, Matta MK, Kole P, Mandlekar S, Furlong MT, Liu T, Iyer RA, Marathe P, Yang Z, Lai Y, Rodrigues AD. Zhang Y, et al. Among authors: rodrigues ad. Drug Metab Dispos. 2016 Mar;44(3):320-8. doi: 10.1124/dmd.115.066944. Epub 2015 Dec 29. Drug Metab Dispos. 2016. PMID: 26714763

8

Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions.

Sinz M, Kim S, Zhu Z, Chen T, Anthony M, Dickinson K, Rodrigues AD. Sinz M, et al. Among authors: rodrigues ad. Curr Drug Metab. 2006 May;7(4):375-88. doi: 10.2174/138920006776873535. Curr Drug Metab. 2006. PMID: 16724927

9

Cynomolgus Monkey as an Emerging Animal Model to Study Drug Transporters: In Vitro, In Vivo, In Vitro-to-In Vivo Translation.

Shen H, Yang Z, Rodrigues AD. Shen H, et al. Among authors: rodrigues ad. Drug Metab Dispos. 2022 Mar;50(3):299-319. doi: 10.1124/dmd.121.000695. Epub 2021 Dec 10. Drug Metab Dispos. 2022. PMID: 34893475 Review.

10

Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.

Shen H, Yao M, Sinz M, Marathe P, Rodrigues AD, Zhu M. Shen H, et al. Among authors: rodrigues ad. Mol Pharm. 2019 Sep 3;16(9):4065-4076. doi: 10.1021/acs.molpharmaceut.9b00472. Epub 2019 Aug 7. Mol Pharm. 2019. PMID: 31335150

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