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Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53.
Kelly GL, Grabow S, Glaser SP, Fitzsimmons L, Aubrey BJ, Okamoto T, Valente LJ, Robati M, Tai L, Fairlie WD, Lee EF, Lindstrom MS, Wiman KG, Huang DC, Bouillet P, Rowe M, Rickinson AB, Herold MJ, Strasser A. Kelly GL, et al. Among authors: glaser sp. Genes Dev. 2014 Jan 1;28(1):58-70. doi: 10.1101/gad.232009.113. Genes Dev. 2014. PMID: 24395247 Free PMC article.
Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.
Mérino D, Khaw SL, Glaser SP, Anderson DJ, Belmont LD, Wong C, Yue P, Robati M, Phipson B, Fairlie WD, Lee EF, Campbell KJ, Vandenberg CJ, Cory S, Roberts AW, Ludlam MJ, Huang DC, Bouillet P. Mérino D, et al. Among authors: glaser sp. Blood. 2012 Jun 14;119(24):5807-16. doi: 10.1182/blood-2011-12-400929. Epub 2012 Apr 26. Blood. 2012. PMID: 22538851 Free PMC article.
Mcl-1 is essential for the survival of plasma cells.
Peperzak V, Vikström I, Walker J, Glaser SP, LePage M, Coquery CM, Erickson LD, Fairfax K, Mackay F, Strasser A, Nutt SL, Tarlinton DM. Peperzak V, et al. Among authors: glaser sp. Nat Immunol. 2013 Mar;14(3):290-7. doi: 10.1038/ni.2527. Epub 2013 Feb 3. Nat Immunol. 2013. PMID: 23377201 Free PMC article.
Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.
Okamoto T, Coultas L, Metcalf D, van Delft MF, Glaser SP, Takiguchi M, Strasser A, Bouillet P, Adams JM, Huang DC. Okamoto T, et al. Among authors: glaser sp. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):261-6. doi: 10.1073/pnas.1321259110. Epub 2013 Dec 20. Proc Natl Acad Sci U S A. 2014. PMID: 24363325 Free PMC article.
MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.
Vikström IB, Slomp A, Carrington EM, Moesbergen LM, Chang C, Kelly GL, Glaser SP, Jansen JH, Leusen JH, Strasser A, Huang DC, Lew AM, Peperzak V, Tarlinton DM. Vikström IB, et al. Among authors: glaser sp. Cell Death Dis. 2016 Aug 25;7(8):e2345. doi: 10.1038/cddis.2016.237. Cell Death Dis. 2016. PMID: 27560714 Free PMC article.
BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage.
Brinkmann K, Waring P, Glaser SP, Wimmer V, Cottle DL, Tham MS, Nhu D, Whitehead L, Delbridge AR, Lessene G, Smyth IM, Herold MJ, Kelly GL, Grabow S, Strasser A. Brinkmann K, et al. Among authors: glaser sp. EMBO J. 2020 Dec 15;39(24):e105561. doi: 10.15252/embj.2020105561. Epub 2020 Nov 25. EMBO J. 2020. PMID: 33236795 Free PMC article.
33 results