Tolmachova T - Search Results

1

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.

MacLaren RE, Groppe M, Barnard AR, Cottriall CL, Tolmachova T, Seymour L, Clark KR, During MJ, Cremers FP, Black GC, Lotery AJ, Downes SM, Webster AR, Seabra MC. MacLaren RE, et al. Among authors: tolmachova t. Lancet. 2014 Mar 29;383(9923):1129-37. doi: 10.1016/S0140-6736(13)62117-0. Epub 2014 Jan 16. Lancet. 2014. PMID: 24439297 Free PMC article. Clinical Trial.

2

Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia.

Tolmachova T, Wavre-Shapton ST, Barnard AR, MacLaren RE, Futter CE, Seabra MC. Tolmachova T, et al. Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4913-20. doi: 10.1167/iovs.09-4892. Epub 2010 May 5. Invest Ophthalmol Vis Sci. 2010. PMID: 20445111 Free PMC article.

3

Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo.

Tolmachova T, Tolmachov OE, Barnard AR, de Silva SR, Lipinski DM, Walker NJ, Maclaren RE, Seabra MC. Tolmachova T, et al. J Mol Med (Berl). 2013 Jul;91(7):825-37. doi: 10.1007/s00109-013-1006-4. Epub 2013 Jun 12. J Mol Med (Berl). 2013. PMID: 23756766 Free PMC article.

4

Visual Acuity after Retinal Gene Therapy for Choroideremia.

Edwards TL, Jolly JK, Groppe M, Barnard AR, Cottriall CL, Tolmachova T, Black GC, Webster AR, Lotery AJ, Holder GE, Xue K, Downes SM, Simunovic MP, Seabra MC, MacLaren RE. Edwards TL, et al. Among authors: tolmachova t. N Engl J Med. 2016 May 19;374(20):1996-8. doi: 10.1056/NEJMc1509501. Epub 2016 Apr 27. N Engl J Med. 2016. PMID: 27120491 Free PMC article. No abstract available.

5

Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia.

Xue K, Jolly JK, Barnard AR, Rudenko A, Salvetti AP, Patrício MI, Edwards TL, Groppe M, Orlans HO, Tolmachova T, Black GC, Webster AR, Lotery AJ, Holder GE, Downes SM, Seabra MC, MacLaren RE. Xue K, et al. Among authors: tolmachova t. Nat Med. 2018 Oct;24(10):1507-1512. doi: 10.1038/s41591-018-0185-5. Epub 2018 Oct 8. Nat Med. 2018. PMID: 30297895 Free PMC article.

6

Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia.

Tolmachova T, Anders R, Abrink M, Bugeon L, Dallman MJ, Futter CE, Ramalho JS, Tonagel F, Tanimoto N, Seeliger MW, Huxley C, Seabra MC. Tolmachova T, et al. J Clin Invest. 2006 Feb;116(2):386-94. doi: 10.1172/JCI26617. Epub 2006 Jan 12. J Clin Invest. 2006. PMID: 16410831 Free PMC article.

7

CHM/REP1 cDNA delivery by lentiviral vectors provides functional expression of the transgene in the retinal pigment epithelium of choroideremia mice.

Tolmachova T, Tolmachov OE, Wavre-Shapton ST, Tracey-White D, Futter CE, Seabra MC. Tolmachova T, et al. J Gene Med. 2012 Mar;14(3):158-68. doi: 10.1002/jgm.1652. J Gene Med. 2012. PMID: 22228595

8

Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium.

Wavre-Shapton ST, Tolmachova T, Lopes da Silva M, Futter CE, Seabra MC. Wavre-Shapton ST, et al. Among authors: tolmachova t. PLoS One. 2013;8(2):e57769. doi: 10.1371/journal.pone.0057769. Epub 2013 Feb 27. PLoS One. 2013. PMID: 23460904 Free PMC article.

9

Chronically shortened rod outer segments accompany photoreceptor cell death in Choroideremia.

Meschede IP, Burgoyne T, Tolmachova T, Seabra MC, Futter CE. Meschede IP, et al. Among authors: tolmachova t. PLoS One. 2020 Nov 17;15(11):e0242284. doi: 10.1371/journal.pone.0242284. eCollection 2020. PLoS One. 2020. PMID: 33201897 Free PMC article.

10

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease.

Hayes MJ, Burgoyne T, Wavre-Shapton ST, Tolmachova T, Seabra MC, Futter CE. Hayes MJ, et al. Among authors: tolmachova t. Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2515-2524. doi: 10.1167/iovs.19-26784. Invest Ophthalmol Vis Sci. 2019. PMID: 31194861 Free PMC article.

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