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PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors.
Martínez-Díez M, Guillén-Navarro MJ, Pera B, Bouchet BP, Martínez-Leal JF, Barasoain I, Cuevas C, Andreu JM, García-Fernández LF, Díaz JF, Avilés P, Galmarini CM. Martínez-Díez M, et al. Among authors: barasoain i. Biochem Pharmacol. 2014 Apr 1;88(3):291-302. doi: 10.1016/j.bcp.2014.01.026. Epub 2014 Jan 31. Biochem Pharmacol. 2014. PMID: 24486569
New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.
Pera B, Barasoain I, Pantazopoulou A, Canales A, Matesanz R, Rodriguez-Salarichs J, García-Fernandez LF, Moneo V, Jiménez-Barbero J, Galmarini CM, Cuevas C, Peñalva MA, Díaz JF, Andreu JM. Pera B, et al. Among authors: barasoain i. ACS Chem Biol. 2013 Sep 20;8(9):2084-94. doi: 10.1021/cb400461j. Epub 2013 Aug 1. ACS Chem Biol. 2013. PMID: 23859655
Fluorescent taxoid probes for microtubule research.
Barasoain I, Díaz JF, Andreu JM. Barasoain I, et al. Methods Cell Biol. 2010;95:353-72. doi: 10.1016/S0091-679X(10)95019-X. Methods Cell Biol. 2010. PMID: 20466144 Review.
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
Matesanz R, Trigili C, Rodríguez-Salarichs J, Zanardi I, Pera B, Nogales A, Fang WS, Jímenez-Barbero J, Canales A, Barasoain I, Ojima I, Díaz JF. Matesanz R, et al. Among authors: barasoain i. Bioorg Med Chem. 2014 Sep 15;22(18):5078-90. doi: 10.1016/j.bmc.2014.05.048. Epub 2014 Jun 19. Bioorg Med Chem. 2014. PMID: 25047938 Free article.
92 results