Lam KH - Search Results

1

Botulinum neurotoxin A complex recognizes host carbohydrates through its hemagglutinin component.

Yao G, Lee K, Gu S, Lam KH, Jin R. Yao G, et al. Among authors: lam kh. Toxins (Basel). 2014 Feb 12;6(2):624-35. doi: 10.3390/toxins6020624. Toxins (Basel). 2014. PMID: 24525478 Free PMC article.

2

High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex.

Lee K, Lam KH, Kruel AM, Perry K, Rummel A, Jin R. Lee K, et al. Among authors: lam kh. Biochem Biophys Res Commun. 2014 Apr 4;446(2):568-73. doi: 10.1016/j.bbrc.2014.03.008. Epub 2014 Mar 12. Biochem Biophys Res Commun. 2014. PMID: 24631690 Free PMC article.

3

Structural basis of the pH-dependent assembly of a botulinum neurotoxin complex.

Matsui T, Gu S, Lam KH, Carter LG, Rummel A, Mathews II, Jin R. Matsui T, et al. Among authors: lam kh. J Mol Biol. 2014 Nov 11;426(22):3773-3782. doi: 10.1016/j.jmb.2014.09.009. Epub 2014 Sep 18. J Mol Biol. 2014. PMID: 25240768 Free PMC article.

4

Diverse binding modes, same goal: The receptor recognition mechanism of botulinum neurotoxin.

Lam KH, Yao G, Jin R. Lam KH, et al. Prog Biophys Mol Biol. 2015 Mar;117(2-3):225-231. doi: 10.1016/j.pbiomolbio.2015.02.004. Epub 2015 Feb 19. Prog Biophys Mol Biol. 2015. PMID: 25701633 Free PMC article. Review.

5

Architecture of the botulinum neurotoxin complex: a molecular machine for protection and delivery.

Lam KH, Jin R. Lam KH, et al. Curr Opin Struct Biol. 2015 Apr;31:89-95. doi: 10.1016/j.sbi.2015.03.013. Epub 2015 Apr 15. Curr Opin Struct Biol. 2015. PMID: 25889616 Free PMC article. Review.

6

Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.

Lee K, Lam KH, Kruel AM, Mahrhold S, Perry K, Cheng LW, Rummel A, Jin R. Lee K, et al. Among authors: lam kh. Toxicon. 2015 Dec 1;107(Pt A):43-9. doi: 10.1016/j.toxicon.2015.08.003. Epub 2015 Aug 10. Toxicon. 2015. PMID: 26272706 Free PMC article.

7

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.

Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R. Yao G, et al. Among authors: lam kh. Nat Struct Mol Biol. 2016 Jul;23(7):656-62. doi: 10.1038/nsmb.3245. Epub 2016 Jun 13. Nat Struct Mol Biol. 2016. PMID: 27294781 Free PMC article.

8

Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.

Yao G, Lam KH, Perry K, Weisemann J, Rummel A, Jin R. Yao G, et al. Among authors: lam kh. Toxins (Basel). 2017 Mar 8;9(3):93. doi: 10.3390/toxins9030093. Toxins (Basel). 2017. PMID: 28282873 Free PMC article.

9

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.

Yao G, Lam KH, Weisemann J, Peng L, Krez N, Perry K, Shoemaker CB, Dong M, Rummel A, Jin R. Yao G, et al. Among authors: lam kh. Sci Rep. 2017 Aug 7;7(1):7438. doi: 10.1038/s41598-017-07457-5. Sci Rep. 2017. PMID: 28785006 Free PMC article.

10

Massively parallel de novo protein design for targeted therapeutics.

Chevalier A, Silva DA, Rocklin GJ, Hicks DR, Vergara R, Murapa P, Bernard SM, Zhang L, Lam KH, Yao G, Bahl CD, Miyashita SI, Goreshnik I, Fuller JT, Koday MT, Jenkins CM, Colvin T, Carter L, Bohn A, Bryan CM, Fernández-Velasco DA, Stewart L, Dong M, Huang X, Jin R, Wilson IA, Fuller DH, Baker D. Chevalier A, et al. Among authors: lam kh. Nature. 2017 Oct 5;550(7674):74-79. doi: 10.1038/nature23912. Epub 2017 Sep 27. Nature. 2017. PMID: 28953867 Free PMC article.

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