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Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility.
Edmond V, Dufour F, Poiroux G, Shoji K, Malleter M, Fouqué A, Tauzin S, Rimokh R, Sergent O, Penna A, Dupuy A, Levade T, Theret N, Micheau O, Ségui B, Legembre P. Edmond V, et al. Among authors: legembre p. Oncogene. 2015 Feb 19;34(8):996-1005. doi: 10.1038/onc.2014.55. Epub 2014 Mar 17. Oncogene. 2015. PMID: 24632610
The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.
Tauzin S, Chaigne-Delalande B, Selva E, Khadra N, Daburon S, Contin-Bordes C, Blanco P, Le Seyec J, Ducret T, Counillon L, Moreau JF, Hofman P, Vacher P, Legembre P. Tauzin S, et al. Among authors: legembre p. PLoS Biol. 2011 Jun;9(6):e1001090. doi: 10.1371/journal.pbio.1001090. Epub 2011 Jun 21. PLoS Biol. 2011. PMID: 21713032 Free PMC article.
CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation.
Khadra N, Bresson-Bepoldin L, Penna A, Chaigne-Delalande B, Ségui B, Levade T, Vacher AM, Reiffers J, Ducret T, Moreau JF, Cahalan MD, Vacher P, Legembre P. Khadra N, et al. Among authors: legembre p. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19072-7. doi: 10.1073/pnas.1116946108. Epub 2011 Nov 7. Proc Natl Acad Sci U S A. 2011. PMID: 22065776 Free PMC article.
The CD95 signaling pathway: To not die and fly.
Penna A, Khadra N, Tauzin S, Vacher P, Legembre P. Penna A, et al. Among authors: legembre p. Commun Integr Biol. 2012 Mar 1;5(2):190-2. doi: 10.4161/cib.18888. Commun Integr Biol. 2012. PMID: 22808330 Free PMC article.
Precise mapping of the CD95 pre-ligand assembly domain.
Edmond V, Ghali B, Penna A, Taupin JL, Daburon S, Moreau JF, Legembre P. Edmond V, et al. Among authors: legembre p. PLoS One. 2012;7(9):e46236. doi: 10.1371/journal.pone.0046236. Epub 2012 Sep 25. PLoS One. 2012. PMID: 23049989 Free PMC article.
CD95L cell surface cleavage triggers a prometastatic signaling pathway in triple-negative breast cancer.
Malleter M, Tauzin S, Bessede A, Castellano R, Goubard A, Godey F, Levêque J, Jézéquel P, Campion L, Campone M, Ducret T, MacGrogan G, Debure L, Collette Y, Vacher P, Legembre P. Malleter M, et al. Among authors: legembre p. Cancer Res. 2013 Nov 15;73(22):6711-21. doi: 10.1158/0008-5472.CAN-13-1794. Epub 2013 Sep 26. Cancer Res. 2013. PMID: 24072745
The CD95/CD95L signaling pathway: a role in carcinogenesis.
Fouqué A, Debure L, Legembre P. Fouqué A, et al. Among authors: legembre p. Biochim Biophys Acta. 2014 Aug;1846(1):130-41. doi: 10.1016/j.bbcan.2014.04.007. Epub 2014 Apr 26. Biochim Biophys Acta. 2014. PMID: 24780723 Free article. Review.
90 results