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The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response.
Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA. Puente BN, et al. Among authors: chen r, chen dj. Cell. 2014 Apr 24;157(3):565-79. doi: 10.1016/j.cell.2014.03.032. Cell. 2014. PMID: 24766806 Free PMC article.
The hypoxic epicardial and subepicardial microenvironment.
Kocabas F, Mahmoud AI, Sosic D, Porrello ER, Chen R, Garcia JA, DeBerardinis RJ, Sadek HA. Kocabas F, et al. Among authors: chen r. J Cardiovasc Transl Res. 2012 Oct;5(5):654-65. doi: 10.1007/s12265-012-9366-7. Epub 2012 May 8. J Cardiovasc Transl Res. 2012. PMID: 22566269
Allosteric inhibition of hypoxia inducible factor-2 with small molecules.
Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK. Scheuermann TH, et al. Among authors: chen r. Nat Chem Biol. 2013 Apr;9(4):271-6. doi: 10.1038/nchembio.1185. Epub 2013 Feb 24. Nat Chem Biol. 2013. PMID: 23434853 Free PMC article.
An acetate switch regulates stress erythropoiesis.
Xu M, Nagati JS, Xie J, Li J, Walters H, Moon YA, Gerard RD, Huang CL, Comerford SA, Hammer RE, Horton JD, Chen R, Garcia JA. Xu M, et al. Among authors: chen r. Nat Med. 2014 Sep;20(9):1018-26. doi: 10.1038/nm.3587. Epub 2014 Aug 10. Nat Med. 2014. PMID: 25108527 Free PMC article.
Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart.
Kimura W, Xiao F, Canseco DC, Muralidhar S, Thet S, Zhang HM, Abderrahman Y, Chen R, Garcia JA, Shelton JM, Richardson JA, Ashour AM, Asaithamby A, Liang H, Xing C, Lu Z, Zhang CC, Sadek HA. Kimura W, et al. Among authors: chen r. Nature. 2015 Jul 9;523(7559):226-30. doi: 10.1038/nature14582. Epub 2015 Jun 22. Nature. 2015. PMID: 26098368
Corrigendum: Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart.
Kimura W, Xiao F, Canseco DC, Muralidhar S, Thet S, Zhang HM, Abderrahman Y, Chen R, Garcia JA, Shelton JM, Richardson JA, Ashour AM, Asaithamby A, Liang H, Xing C, Lu Z, Cheng Zhang C, Sadek HA. Kimura W, et al. Among authors: chen r. Nature. 2016 Apr 14;532(7598):268. doi: 10.1038/nature16177. Epub 2015 Dec 23. Nature. 2016. PMID: 26700813 No abstract available.
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