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Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.
Berger SB, Kasparcova V, Hoffman S, Swift B, Dare L, Schaeffer M, Capriotti C, Cook M, Finger J, Hughes-Earle A, Harris PA, Kaiser WJ, Mocarski ES, Bertin J, Gough PJ. Berger SB, et al. Among authors: hughes earle a. J Immunol. 2014 Jun 15;192(12):5476-80. doi: 10.4049/jimmunol.1400499. Epub 2014 May 12. J Immunol. 2014. PMID: 24821972 Free PMC article.
Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions.
King AJ, Arnone MR, Bleam MR, Moss KG, Yang J, Fedorowicz KE, Smitheman KN, Erhardt JA, Hughes-Earle A, Kane-Carson LS, Sinnamon RH, Qi H, Rheault TR, Uehling DE, Laquerre SG. King AJ, et al. Among authors: hughes earle a. PLoS One. 2013 Jul 3;8(7):e67583. doi: 10.1371/journal.pone.0067583. Print 2013. PLoS One. 2013. PMID: 23844038 Free PMC article.
Potential candidate genomic biomarkers of drug induced vascular injury in the rat.
Dalmas DA, Scicchitano MS, Mullins D, Hughes-Earle A, Tatsuoka K, Magid-Slav M, Frazier KS, Thomas HC. Dalmas DA, et al. Among authors: hughes earle a. Toxicol Appl Pharmacol. 2011 Dec 1;257(2):284-300. doi: 10.1016/j.taap.2011.09.015. Epub 2011 Sep 24. Toxicol Appl Pharmacol. 2011. PMID: 21983523
Spontaneous cardiomyopathy in young Sprague-Dawley rats: evaluation of biological and environmental variability.
Chanut F, Kimbrough C, Hailey R, Berridge B, Hughes-Earle A, Davies R, Roland K, Stokes A, Casartelli A, York M, Jordan H, Crivellente F, Cristofori P, Thomas H, Klapwijk J, Adler R. Chanut F, et al. Among authors: hughes earle a. Toxicol Pathol. 2013;41(8):1126-36. doi: 10.1177/0192623313478692. Epub 2013 Mar 7. Toxicol Pathol. 2013. PMID: 23475560