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Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space.
Pruessmeyer J, Hess FM, Alert H, Groth E, Pasqualon T, Schwarz N, Nyamoya S, Kollert J, van der Vorst E, Donners M, Martin C, Uhlig S, Saftig P, Dreymueller D, Ludwig A. Pruessmeyer J, et al. Among authors: saftig p. Blood. 2014 Jun 26;123(26):4077-88. doi: 10.1182/blood-2013-09-511543. Epub 2014 May 15. Blood. 2014. PMID: 24833351 Free article.
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A. Hundhausen C, et al. Among authors: saftig p. Blood. 2003 Aug 15;102(4):1186-95. doi: 10.1182/blood-2002-12-3775. Epub 2003 Apr 24. Blood. 2003. PMID: 12714508 Free article.
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, Ludwig A. Abel S, et al. Among authors: saftig p. J Immunol. 2004 May 15;172(10):6362-72. doi: 10.4049/jimmunol.172.10.6362. J Immunol. 2004. PMID: 15128827
Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).
Budagian V, Bulanova E, Orinska Z, Ludwig A, Rose-John S, Saftig P, Borden EC, Bulfone-Paus S. Budagian V, et al. Among authors: saftig p. J Biol Chem. 2004 Sep 24;279(39):40368-75. doi: 10.1074/jbc.M404125200. Epub 2004 Jun 23. J Biol Chem. 2004. Retraction in: J Biol Chem. 2011 Mar 18;286(11):9894. doi: 10.1074/jbc.a110.404125. PMID: 15215246 Free article. Retracted.
Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum.
Budagian V, Bulanova E, Orinska Z, Duitman E, Brandt K, Ludwig A, Hartmann D, Lemke G, Saftig P, Bulfone-Paus S. Budagian V, et al. Among authors: saftig p. Mol Cell Biol. 2005 Nov;25(21):9324-39. doi: 10.1128/MCB.25.21.9324-9339.2005. Mol Cell Biol. 2005. Retraction in: Mol Cell Biol. 2011 Mar;31(6):1330. doi: 10.1128/MCB.05019-11. PMID: 16227584 Free PMC article. Retracted.
346 results