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Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.
McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Pétrilli V, Andrew PW, Kadioglu A, Lavelle EC. McNeela EA, et al. Among authors: neill dr. PLoS Pathog. 2010 Nov 11;6(11):e1001191. doi: 10.1371/journal.ppat.1001191. PLoS Pathog. 2010. PMID: 21085613 Free PMC article.
Controlled human infection and rechallenge with Streptococcus pneumoniae reveals the protective efficacy of carriage in healthy adults.
Ferreira DM, Neill DR, Bangert M, Gritzfeld JF, Green N, Wright AK, Pennington SH, Bricio-Moreno L, Moreno AT, Miyaji EN, Wright AD, Collins AM, Goldblatt D, Kadioglu A, Gordon SB. Ferreira DM, et al. Among authors: neill dr. Am J Respir Crit Care Med. 2013 Apr 15;187(8):855-64. doi: 10.1164/rccm.201212-2277OC. Am J Respir Crit Care Med. 2013. PMID: 23370916 Free PMC article.
51 results