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Page 1
Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A. Mehel H, et al. J Am Coll Cardiol. 2013 Oct 22;62(17):1596-606. doi: 10.1016/j.jacc.2013.05.057. Epub 2013 Jun 26. J Am Coll Cardiol. 2013. PMID: 23810893 Free article.
Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases.
Ghigo A, Perino A, Mehel H, Zahradníková A Jr, Morello F, Leroy J, Nikolaev VO, Damilano F, Cimino J, De Luca E, Richter W, Westenbroek R, Catterall WA, Zhang J, Yan C, Conti M, Gomez AM, Vandecasteele G, Hirsch E, Fischmeister R. Ghigo A, et al. Among authors: mehel h. Circulation. 2012 Oct 23;126(17):2073-83. doi: 10.1161/CIRCULATIONAHA.112.114074. Epub 2012 Sep 24. Circulation. 2012. PMID: 23008439 Free PMC article.
Phosphodiesterase 2: anti-adrenergic friend or hypertrophic foe in heart disease?
Wagner M, Mehel H, Fischmeister R, El-Armouche A. Wagner M, et al. Among authors: mehel h. Naunyn Schmiedebergs Arch Pharmacol. 2016 Nov;389(11):1139-1141. doi: 10.1007/s00210-016-1289-4. Epub 2016 Aug 24. Naunyn Schmiedebergs Arch Pharmacol. 2016. PMID: 27553701 Free article. No abstract available.
Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction.
Mougenot N, Mika D, Czibik G, Marcos E, Abid S, Houssaini A, Vallin B, Guellich A, Mehel H, Sawaki D, Vandecasteele G, Fischmeister R, Hajjar RJ, Dubois-Randé JL, Limon I, Adnot S, Derumeaux G, Lipskaia L. Mougenot N, et al. Among authors: mehel h. Cardiovasc Res. 2019 Oct 1;115(12):1778-1790. doi: 10.1093/cvr/cvy306. Cardiovasc Res. 2019. PMID: 30605506 Free PMC article.
Dominant negative Ras attenuates pathological ventricular remodeling in pressure overload cardiac hypertrophy.
Ramos-Kuri M, Rapti K, Mehel H, Zhang S, Dhandapany PS, Liang L, García-Carrancá A, Bobe R, Fischmeister R, Adnot S, Lebeche D, Hajjar RJ, Lipskaia L, Chemaly ER. Ramos-Kuri M, et al. Among authors: mehel h. Biochim Biophys Acta. 2015 Nov;1853(11 Pt A):2870-84. doi: 10.1016/j.bbamcr.2015.08.006. Epub 2015 Aug 8. Biochim Biophys Acta. 2015. PMID: 26260012 Free PMC article.
Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction.
Vettel C, Lindner M, Dewenter M, Lorenz K, Schanbacher C, Riedel M, Lämmle S, Meinecke S, Mason FE, Sossalla S, Geerts A, Hoffmann M, Wunder F, Brunner FJ, Wieland T, Mehel H, Karam S, Lechêne P, Leroy J, Vandecasteele G, Wagner M, Fischmeister R, El-Armouche A. Vettel C, et al. Among authors: mehel h. Circ Res. 2017 Jan 6;120(1):120-132. doi: 10.1161/CIRCRESAHA.116.310069. Epub 2016 Oct 31. Circ Res. 2017. PMID: 27799254
Carboxy-terminal fragment of fibroblast growth factor 23 induces heart hypertrophy in sickle cell disease.
Courbebaisse M, Mehel H, Petit-Hoang C, Ribeil JA, Sabbah L, Tuloup-Minguez V, Bergerat D, Arlet JB, Stanislas A, Souberbielle JC, Le Clésiau H, Fischmeister R, Friedlander G, Prié D. Courbebaisse M, et al. Among authors: mehel h. Haematologica. 2017 Feb;102(2):e33-e35. doi: 10.3324/haematol.2016.150987. Epub 2016 Oct 27. Haematologica. 2017. PMID: 27789679 Free PMC article. No abstract available.