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NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.
Nausch B, Rode F, Jørgensen S, Nardi A, Korsgaard MP, Hougaard C, Bonev AD, Brown WD, Dyhring T, Strøbæk D, Olesen SP, Christophersen P, Grunnet M, Nelson MT, Rønn LC. Nausch B, et al. Among authors: rode f. J Pharmacol Exp Ther. 2014 Sep;350(3):520-30. doi: 10.1124/jpet.113.212662. Epub 2014 Jun 20. J Pharmacol Exp Ther. 2014. PMID: 24951278 Free PMC article.
A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo.
Hougaard C, Fraser MO, Chien C, Bookout A, Katofiasc M, Jensen BS, Rode F, Bitsch-Nørhave J, Teuber L, Thor KB, Strøbaek D, Burgard EC, Rønn LC. Hougaard C, et al. Among authors: rode f. J Pharmacol Exp Ther. 2009 Jan;328(1):28-39. doi: 10.1124/jpet.108.143123. Epub 2008 Sep 26. J Pharmacol Exp Ther. 2009. PMID: 18820135
Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2.
Kasumu AW, Hougaard C, Rode F, Jacobsen TA, Sabatier JM, Eriksen BL, Strøbæk D, Liang X, Egorova P, Vorontsova D, Christophersen P, Rønn LC, Bezprozvanny I. Kasumu AW, et al. Among authors: rode f. Chem Biol. 2012 Oct 26;19(10):1340-53. doi: 10.1016/j.chembiol.2012.07.013. Chem Biol. 2012. PMID: 23102227 Free PMC article.
23 results