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Orvinols with mixed kappa/mu opioid receptor agonist activity.
Greedy BM, Bradbury F, Thomas MP, Grivas K, Cami-Kobeci G, Archambeau A, Bosse K, Clark MJ, Aceto M, Lewis JW, Traynor JR, Husbands SM. Greedy BM, et al. Among authors: clark mj. J Med Chem. 2013 Apr 25;56(8):3207-16. doi: 10.1021/jm301543e. Epub 2013 Apr 3. J Med Chem. 2013. PMID: 23438330 Free PMC article.
Characterization of BU09059: a novel potent selective κ-receptor antagonist.
Casal-Dominguez JJ, Furkert D, Ostovar M, Teintang L, Clark MJ, Traynor JR, Husbands SM, Bailey SJ. Casal-Dominguez JJ, et al. Among authors: clark mj. ACS Chem Neurosci. 2014 Mar 19;5(3):177-84. doi: 10.1021/cn4001507. Epub 2014 Jan 28. ACS Chem Neurosci. 2014. PMID: 24410326 Free PMC article.
Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity.
Kumar V, Ridzwan IE, Grivas K, Lewis JW, Clark MJ, Meurice C, Jimenez-Gomez C, Pogozheva I, Mosberg H, Traynor JR, Husbands SM. Kumar V, et al. Among authors: clark mj. J Med Chem. 2014 May 22;57(10):4049-57. doi: 10.1021/jm401964y. Epub 2014 May 9. J Med Chem. 2014. PMID: 24761755 Free PMC article.
C7β-methyl analogues of the orvinols: the discovery of kappa opioid antagonists with nociceptin/orphanin FQ peptide (NOP) receptor partial agonism and low, or zero, efficacy at mu opioid receptors.
Cueva JP, Roche C, Ostovar M, Kumar V, Clark MJ, Hillhouse TM, Lewis JW, Traynor JR, Husbands SM. Cueva JP, et al. Among authors: clark mj. J Med Chem. 2015 May 28;58(10):4242-9. doi: 10.1021/acs.jmedchem.5b00130. Epub 2015 May 6. J Med Chem. 2015. PMID: 25898137 Free PMC article.
280 results