Robert R - Search Results

1

Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.

Carlile GW, Robert R, Goepp J, Matthes E, Liao J, Kus B, Macknight SD, Rotin D, Hanrahan JW, Thomas DY. Carlile GW, et al. Among authors: robert r. J Cyst Fibros. 2015 Jan;14(1):16-25. doi: 10.1016/j.jcf.2014.06.001. Epub 2014 Jun 25. J Cyst Fibros. 2015. PMID: 24974227 Free article.

2

Cystic fibrosis transmembrane conductance regulator trafficking modulates the barrier function of airway epithelial cell monolayers.

LeSimple P, Liao J, Robert R, Gruenert DC, Hanrahan JW. LeSimple P, et al. Among authors: robert r. J Physiol. 2010 Apr 15;588(Pt 8):1195-209. doi: 10.1113/jphysiol.2009.182246. Epub 2010 Feb 15. J Physiol. 2010. PMID: 20156845 Free PMC article.

3

Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine.

Robert R, Carlile GW, Liao J, Balghi H, Lesimple P, Liu N, Kus B, Rotin D, Wilke M, de Jonge HR, Scholte BJ, Thomas DY, Hanrahan JW. Robert R, et al. Mol Pharmacol. 2010 Jun;77(6):922-30. doi: 10.1124/mol.109.062679. Epub 2010 Mar 3. Mol Pharmacol. 2010. PMID: 20200141

4

Identification of a NBD1-binding pharmacological chaperone that corrects the trafficking defect of F508del-CFTR.

Sampson HM, Robert R, Liao J, Matthes E, Carlile GW, Hanrahan JW, Thomas DY. Sampson HM, et al. Among authors: robert r. Chem Biol. 2011 Feb 25;18(2):231-42. doi: 10.1016/j.chembiol.2010.11.016. Chem Biol. 2011. PMID: 21338920

5

Correction of F508del-CFTR trafficking by the sponge alkaloid latonduine is modulated by interaction with PARP.

Carlile GW, Keyzers RA, Teske KA, Robert R, Williams DE, Linington RG, Gray CA, Centko RM, Yan L, Anjos SM, Sampson HM, Zhang D, Liao J, Hanrahan JW, Andersen RJ, Thomas DY. Carlile GW, et al. Among authors: robert r. Chem Biol. 2012 Oct 26;19(10):1288-99. doi: 10.1016/j.chembiol.2012.08.014. Chem Biol. 2012. PMID: 23102222

6

Cystic fibrosis transmembrane conductance regulator is expressed in mucin granules from Calu-3 and primary human airway epithelial cells.

LeSimple P, Goepp J, Palmer ML, Fahrenkrug SC, O'Grady SM, Ferraro P, Robert R, Hanrahan JW. LeSimple P, et al. Among authors: robert r. Am J Respir Cell Mol Biol. 2013 Oct;49(4):511-6. doi: 10.1165/rcmb.2012-0419RC. Am J Respir Cell Mol Biol. 2013. PMID: 23742042

7

Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor).

Matthes E, Goepp J, Carlile GW, Luo Y, Dejgaard K, Billet A, Robert R, Thomas DY, Hanrahan JW. Matthes E, et al. Among authors: robert r. Br J Pharmacol. 2016 Feb;173(3):459-70. doi: 10.1111/bph.13365. Epub 2016 Jan 13. Br J Pharmacol. 2016. PMID: 26492939 Free PMC article.

8

Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity.

Carlile GW, Robert R, Matthes E, Yang Q, Solari R, Hatley R, Edge CM, Hanrahan JW, Andersen R, Thomas DY, Birault V. Carlile GW, et al. Among authors: robert r. Mol Pharmacol. 2016 Aug;90(2):65-79. doi: 10.1124/mol.115.102418. Epub 2016 May 18. Mol Pharmacol. 2016. PMID: 27193581

9

A novel triple combination of pharmacological chaperones improves F508del-CFTR correction.

Carlile GW, Yang Q, Matthes E, Liao J, Radinovic S, Miyamoto C, Robert R, Hanrahan JW, Thomas DY. Carlile GW, et al. Among authors: robert r. Sci Rep. 2018 Jul 30;8(1):11404. doi: 10.1038/s41598-018-29276-y. Sci Rep. 2018. PMID: 30061653 Free PMC article.

10

Correctors of protein trafficking defects identified by a novel high-throughput screening assay.

Carlile GW, Robert R, Zhang D, Teske KA, Luo Y, Hanrahan JW, Thomas DY. Carlile GW, et al. Among authors: robert r. Chembiochem. 2007 Jun 18;8(9):1012-20. doi: 10.1002/cbic.200700027. Chembiochem. 2007. PMID: 17497613

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