Thomas DY - Search Results

1

Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.

Carlile GW, Robert R, Goepp J, Matthes E, Liao J, Kus B, Macknight SD, Rotin D, Hanrahan JW, Thomas DY. Carlile GW, et al. Among authors: thomas dy. J Cyst Fibros. 2015 Jan;14(1):16-25. doi: 10.1016/j.jcf.2014.06.001. Epub 2014 Jun 25. J Cyst Fibros. 2015. PMID: 24974227 Free article.

2

Correction of F508del-CFTR trafficking by the sponge alkaloid latonduine is modulated by interaction with PARP.

Carlile GW, Keyzers RA, Teske KA, Robert R, Williams DE, Linington RG, Gray CA, Centko RM, Yan L, Anjos SM, Sampson HM, Zhang D, Liao J, Hanrahan JW, Andersen RJ, Thomas DY. Carlile GW, et al. Among authors: thomas dy. Chem Biol. 2012 Oct 26;19(10):1288-99. doi: 10.1016/j.chembiol.2012.08.014. Chem Biol. 2012. PMID: 23102222

3

Novel pharmacological strategies to treat cystic fibrosis.

Hanrahan JW, Sampson HM, Thomas DY. Hanrahan JW, et al. Among authors: thomas dy. Trends Pharmacol Sci. 2013 Feb;34(2):119-25. doi: 10.1016/j.tips.2012.11.006. Trends Pharmacol Sci. 2013. PMID: 23380248 Review.

4

Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor).

Matthes E, Goepp J, Carlile GW, Luo Y, Dejgaard K, Billet A, Robert R, Thomas DY, Hanrahan JW. Matthes E, et al. Among authors: thomas dy. Br J Pharmacol. 2016 Feb;173(3):459-70. doi: 10.1111/bph.13365. Epub 2016 Jan 13. Br J Pharmacol. 2016. PMID: 26492939 Free PMC article.

5

Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity.

Carlile GW, Robert R, Matthes E, Yang Q, Solari R, Hatley R, Edge CM, Hanrahan JW, Andersen R, Thomas DY, Birault V. Carlile GW, et al. Among authors: thomas dy. Mol Pharmacol. 2016 Aug;90(2):65-79. doi: 10.1124/mol.115.102418. Epub 2016 May 18. Mol Pharmacol. 2016. PMID: 27193581

6

A novel triple combination of pharmacological chaperones improves F508del-CFTR correction.

Carlile GW, Yang Q, Matthes E, Liao J, Radinovic S, Miyamoto C, Robert R, Hanrahan JW, Thomas DY. Carlile GW, et al. Among authors: thomas dy. Sci Rep. 2018 Jul 30;8(1):11404. doi: 10.1038/s41598-018-29276-y. Sci Rep. 2018. PMID: 30061653 Free PMC article.

7

Cystic Fibrosis: Proteostatic correctors of CFTR trafficking and alternative therapeutic targets.

Hanrahan JW, Sato Y, Carlile GW, Jansen G, Young JC, Thomas DY. Hanrahan JW, et al. Among authors: thomas dy. Expert Opin Ther Targets. 2019 Aug;23(8):711-724. doi: 10.1080/14728222.2019.1628948. Epub 2019 Jun 9. Expert Opin Ther Targets. 2019. PMID: 31169041 Review.

8

The NSAID glafenine rescues class 2 CFTR mutants via cyclooxygenase 2 inhibition of the arachidonic acid pathway.

Carlile GW, Yang Q, Matthes E, Liao J, Birault V, Sneddon HF, Poole DL, Hall CJ, Hanrahan JW, Thomas DY. Carlile GW, et al. Among authors: thomas dy. Sci Rep. 2022 Mar 17;12(1):4595. doi: 10.1038/s41598-022-08661-8. Sci Rep. 2022. PMID: 35302062 Free PMC article.

9

Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine.

Robert R, Carlile GW, Liao J, Balghi H, Lesimple P, Liu N, Kus B, Rotin D, Wilke M, de Jonge HR, Scholte BJ, Thomas DY, Hanrahan JW. Robert R, et al. Among authors: thomas dy. Mol Pharmacol. 2010 Jun;77(6):922-30. doi: 10.1124/mol.109.062679. Epub 2010 Mar 3. Mol Pharmacol. 2010. PMID: 20200141

10

Identification of a NBD1-binding pharmacological chaperone that corrects the trafficking defect of F508del-CFTR.

Sampson HM, Robert R, Liao J, Matthes E, Carlile GW, Hanrahan JW, Thomas DY. Sampson HM, et al. Among authors: thomas dy. Chem Biol. 2011 Feb 25;18(2):231-42. doi: 10.1016/j.chembiol.2010.11.016. Chem Biol. 2011. PMID: 21338920

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