Shpiro N - Search Results

1

Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK.

Hunter RW, Foretz M, Bultot L, Fullerton MD, Deak M, Ross FA, Hawley SA, Shpiro N, Viollet B, Barron D, Kemp BE, Steinberg GR, Hardie DG, Sakamoto K. Hunter RW, et al. Among authors: shpiro n. Chem Biol. 2014 Jul 17;21(7):866-79. doi: 10.1016/j.chembiol.2014.05.014. Chem Biol. 2014. PMID: 25036776 Free PMC article.

2

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis.

McManus EJ, Sakamoto K, Armit LJ, Ronaldson L, Shpiro N, Marquez R, Alessi DR. McManus EJ, et al. Among authors: shpiro n. EMBO J. 2005 Apr 20;24(8):1571-83. doi: 10.1038/sj.emboj.7600633. Epub 2005 Mar 24. EMBO J. 2005. PMID: 15791206 Free PMC article.

3

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

Göransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, Sakamoto K. Göransson O, et al. Among authors: shpiro n. J Biol Chem. 2007 Nov 9;282(45):32549-60. doi: 10.1074/jbc.M706536200. Epub 2007 Sep 12. J Biol Chem. 2007. PMID: 17855357 Free PMC article.

4

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice.

Huang X, Wullschleger S, Shpiro N, McGuire VA, Sakamoto K, Woods YL, McBurnie W, Fleming S, Alessi DR. Huang X, et al. Among authors: shpiro n. Biochem J. 2008 Jun 1;412(2):211-21. doi: 10.1042/BJ20080557. Biochem J. 2008. PMID: 18387000

5

Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity.

Houde VP, Ritorto MS, Gourlay R, Varghese J, Davies P, Shpiro N, Sakamoto K, Alessi DR. Houde VP, et al. Among authors: shpiro n. Biochem J. 2014 Feb 15;458(1):41-56. doi: 10.1042/BJ20131324. Biochem J. 2014. PMID: 24295069 Free PMC article.

6

Targeted dephosphorylation of TFEB promotes its nuclear translocation.

Zhao JF, Shpiro N, Sathe G, Brewer A, Macartney TJ, Wood NT, Negoita F, Sakamoto K, Sapkota GP. Zhao JF, et al. Among authors: shpiro n. iScience. 2024 Jun 29;27(8):110432. doi: 10.1016/j.isci.2024.110432. eCollection 2024 Aug 16. iScience. 2024. PMID: 39081292 Free PMC article.

7

BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo.

Kuma Y, Sabio G, Bain J, Shpiro N, Márquez R, Cuenda A. Kuma Y, et al. Among authors: shpiro n. J Biol Chem. 2005 May 20;280(20):19472-9. doi: 10.1074/jbc.M414221200. Epub 2005 Mar 8. J Biol Chem. 2005. PMID: 15755732 Free article.

8

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors.

Najafov A, Shpiro N, Alessi DR. Najafov A, et al. Among authors: shpiro n. Biochem J. 2012 Dec 1;448(2):285-95. doi: 10.1042/BJ20121287. Biochem J. 2012. PMID: 23030823

9

Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader.

Tovell H, Testa A, Zhou H, Shpiro N, Crafter C, Ciulli A, Alessi DR. Tovell H, et al. Among authors: shpiro n. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034. doi: 10.1021/acschembio.9b00505. Epub 2019 Sep 5. ACS Chem Biol. 2019. PMID: 31461270 Free PMC article.

10

The selectivity of protein kinase inhibitors: a further update.

Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P. Bain J, et al. Among authors: shpiro n. Biochem J. 2007 Dec 15;408(3):297-315. doi: 10.1042/BJ20070797. Biochem J. 2007. PMID: 17850214 Free PMC article.

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