Barlow N - Search Results

1

Enhanced Cytotoxicity through Conjugation of a "Clickable" Luminescent Re(I) Complex to a Cell-Penetrating Lipopeptide.

Leonidova A, Pierroz V, Adams LA, Barlow N, Ferrari S, Graham B, Gasser G. Leonidova A, et al. Among authors: barlow n. ACS Med Chem Lett. 2014 May 15;5(7):809-14. doi: 10.1021/ml500158w. eCollection 2014 Jul 10. ACS Med Chem Lett. 2014. PMID: 25050170 Free PMC article.

2

DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra.

Graham B, Loh CT, Swarbrick JD, Ung P, Shin J, Yagi H, Jia X, Chhabra S, Barlow N, Pintacuda G, Huber T, Otting G. Graham B, et al. Among authors: barlow n. Bioconjug Chem. 2011 Oct 19;22(10):2118-25. doi: 10.1021/bc200353c. Epub 2011 Sep 20. Bioconjug Chem. 2011. PMID: 21877751

3

Lanthanide tags for site-specific ligation to an unnatural amino acid and generation of pseudocontact shifts in proteins.

Loh CT, Ozawa K, Tuck KL, Barlow N, Huber T, Otting G, Graham B. Loh CT, et al. Among authors: barlow n. Bioconjug Chem. 2013 Feb 20;24(2):260-8. doi: 10.1021/bc300631z. Epub 2013 Jan 16. Bioconjug Chem. 2013. PMID: 23294422

4

Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK.

Chhabra S, Barlow N, Dolezal O, Hattarki MK, Newman J, Peat TS, Graham B, Swarbrick JD. Chhabra S, et al. Among authors: barlow n. PLoS One. 2013;8(4):e59535. doi: 10.1371/journal.pone.0059535. Epub 2013 Apr 2. PLoS One. 2013. PMID: 23565155 Free PMC article.

5

Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

Dennis ML, Chhabra S, Wang ZC, Debono A, Dolezal O, Newman J, Pitcher NP, Rahmani R, Cleary B, Barlow N, Hattarki M, Graham B, Peat TS, Baell JB, Swarbrick JD. Dennis ML, et al. Among authors: barlow n. J Med Chem. 2014 Nov 26;57(22):9612-26. doi: 10.1021/jm501417f. Epub 2014 Nov 12. J Med Chem. 2014. PMID: 25357262

6

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution.

Brewer KD, Bacaj T, Cavalli A, Camilloni C, Swarbrick JD, Liu J, Zhou A, Zhou P, Barlow N, Xu J, Seven AB, Prinslow EA, Voleti R, Häussinger D, Bonvin AM, Tomchick DR, Vendruscolo M, Graham B, Südhof TC, Rizo J. Brewer KD, et al. Among authors: barlow n. Nat Struct Mol Biol. 2015 Jul;22(7):555-64. doi: 10.1038/nsmb.3035. Epub 2015 Jun 1. Nat Struct Mol Biol. 2015. PMID: 26030874 Free PMC article.

7

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe.

Barlow N, Nasser Y, Zhao P, Sharma N, Guerrero-Alba R, Edgington-Mitchell LE, Lieu T, Veldhuis NA, Poole DP, Conner JW, Lindström E, Craig AW, Graham B, Vanner SJ, Bunnett NW. Barlow N, et al. Neurogastroenterol Motil. 2015 Nov;27(11):1675-80. doi: 10.1111/nmo.12656. Epub 2015 Aug 24. Neurogastroenterol Motil. 2015. PMID: 26303377

8

Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation.

Edgington-Mitchell LE, Barlow N, Aurelio L, Samha A, Szabo M, Graham B, Bunnett N. Edgington-Mitchell LE, et al. Among authors: barlow n. Bioorg Med Chem Lett. 2017 Jan 15;27(2):254-260. doi: 10.1016/j.bmcl.2016.11.064. Epub 2016 Nov 25. Bioorg Med Chem Lett. 2017. PMID: 27923620 Free PMC article.

9

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.

Dennis ML, Lee MD, Harjani JR, Ahmed M, DeBono AJ, Pitcher NP, Wang ZC, Chhabra S, Barlow N, Rahmani R, Cleary B, Dolezal O, Hattarki M, Aurelio L, Shonberg J, Graham B, Peat TS, Baell JB, Swarbrick JD. Dennis ML, et al. Among authors: barlow n. Chemistry. 2018 Feb 6;24(8):1922-1930. doi: 10.1002/chem.201704730. Epub 2018 Jan 9. Chemistry. 2018. PMID: 29171692

10

Targeting Melanocortin Receptors Using S_NAr-Type Macrocyclization: A Doubly Orthogonal Route to Cyclic Peptide Conjugates.

Yue WK, Zhang T, Shandre Mugan R, Barlow N, Chalmers DK, Pouton CW, Thompson PE. Yue WK, et al. Among authors: barlow n. J Med Chem. 2023 Mar 9;66(5):3273-3283. doi: 10.1021/acs.jmedchem.2c01587. Epub 2023 Feb 21. J Med Chem. 2023. PMID: 36808973

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