Vickers TA - Search Results

1

Defining the factors that contribute to on-target specificity of antisense oligonucleotides.

Lima WF, Vickers TA, Nichols J, Li C, Crooke ST. Lima WF, et al. Among authors: vickers ta. PLoS One. 2014 Jul 29;9(7):e101752. doi: 10.1371/journal.pone.0101752. eCollection 2014. PLoS One. 2014. PMID: 25072142 Free PMC article.

2

Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis.

Vickers TA, Koo S, Bennett CF, Crooke ST, Dean NM, Baker BF. Vickers TA, et al. J Biol Chem. 2003 Feb 28;278(9):7108-18. doi: 10.1074/jbc.M210326200. Epub 2002 Dec 23. J Biol Chem. 2003. PMID: 12500975 Free article.

3

Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.

Vickers TA, Lima WF, Wu H, Nichols JG, Linsley PS, Crooke ST. Vickers TA, et al. Nucleic Acids Res. 2009 Nov;37(20):6927-41. doi: 10.1093/nar/gkp735. Epub 2009 Sep 18. Nucleic Acids Res. 2009. PMID: 19767612 Free PMC article.

4

Antisense oligonucleotides capable of promoting specific target mRNA reduction via competing RNase H1-dependent and independent mechanisms.

Vickers TA, Crooke ST. Vickers TA, et al. PLoS One. 2014 Oct 9;9(10):e108625. doi: 10.1371/journal.pone.0108625. eCollection 2014. PLoS One. 2014. PMID: 25299183 Free PMC article.

5

Targeting of repeated sequences unique to a gene results in significant increases in antisense oligonucleotide potency.

Vickers TA, Freier SM, Bui HH, Watt A, Crooke ST. Vickers TA, et al. PLoS One. 2014 Oct 15;9(10):e110615. doi: 10.1371/journal.pone.0110615. eCollection 2014. PLoS One. 2014. PMID: 25334092 Free PMC article.

6

The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA.

Vickers TA, Crooke ST. Vickers TA, et al. Nucleic Acids Res. 2015 Oct 15;43(18):8955-63. doi: 10.1093/nar/gkv920. Epub 2015 Sep 17. Nucleic Acids Res. 2015. PMID: 26384424 Free PMC article.

7

Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames.

Liang XH, Shen W, Sun H, Migawa MT, Vickers TA, Crooke ST. Liang XH, et al. Among authors: vickers ta. Nat Biotechnol. 2016 Aug;34(8):875-80. doi: 10.1038/nbt.3589. Epub 2016 Jul 11. Nat Biotechnol. 2016. PMID: 27398791

8

Cellular uptake and trafficking of antisense oligonucleotides.

Crooke ST, Wang S, Vickers TA, Shen W, Liang XH. Crooke ST, et al. Among authors: vickers ta. Nat Biotechnol. 2017 Mar;35(3):230-237. doi: 10.1038/nbt.3779. Epub 2017 Feb 27. Nat Biotechnol. 2017. PMID: 28244996 Review.

9

mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway.

Liang XH, Nichols JG, Hsu CW, Vickers TA, Crooke ST. Liang XH, et al. Among authors: vickers ta. Nucleic Acids Res. 2019 Jul 26;47(13):6900-6916. doi: 10.1093/nar/gkz500. Nucleic Acids Res. 2019. PMID: 31165876 Free PMC article.

10

Phosphorothioate modified oligonucleotide-protein interactions.

Crooke ST, Vickers TA, Liang XH. Crooke ST, et al. Among authors: vickers ta. Nucleic Acids Res. 2020 Jun 4;48(10):5235-5253. doi: 10.1093/nar/gkaa299. Nucleic Acids Res. 2020. PMID: 32356888 Free PMC article.

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