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Determination of SGK1 mRNA in non-small cell lung cancer samples underlines high expression in squamous cell carcinomas.
Abbruzzese C, Mattarocci S, Pizzuti L, Mileo AM, Visca P, Antoniani B, Alessandrini G, Facciolo F, Amato R, D'Antona L, Rinaldi M, Felsani A, Perrotti N, Paggi MG. Abbruzzese C, et al. Among authors: perrotti n. J Exp Clin Cancer Res. 2012 Jan 12;31(1):4. doi: 10.1186/1756-9966-31-4. J Exp Clin Cancer Res. 2012. PMID: 22240294 Free PMC article.
SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation.
D'Antona L, Amato R, Talarico C, Ortuso F, Menniti M, Dattilo V, Iuliano R, Gigliotti F, Artese A, Costa G, Schenone S, Musumeci F, Abbruzzese C, Botta L, Trapasso F, Alcaro S, Paggi MG, Perrotti N. D'Antona L, et al. Among authors: perrotti n. Cell Physiol Biochem. 2015;35(5):2006-18. doi: 10.1159/000374008. Epub 2015 Mar 27. Cell Physiol Biochem. 2015. PMID: 25871776 Free article.
The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells.
Matteoni S, Abbruzzese C, Matarrese P, De Luca G, Mileo AM, Miccadei S, Schenone S, Musumeci F, Haas TL, Sette G, Carapella CM, Amato R, Perrotti N, Signore M, Paggi MG. Matteoni S, et al. Among authors: perrotti n. J Exp Clin Cancer Res. 2019 May 17;38(1):202. doi: 10.1186/s13046-019-1212-1. J Exp Clin Cancer Res. 2019. PMID: 31101126 Free PMC article.
The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme.
Abbruzzese C, Catalogna G, Gallo E, di Martino S, Mileo AM, Carosi M, Dattilo V, Schenone S, Musumeci F, Lavia P, Perrotti N, Amato R, Paggi MG. Abbruzzese C, et al. Among authors: perrotti n. Oncotarget. 2017 Nov 18;8(67):110743-110755. doi: 10.18632/oncotarget.22500. eCollection 2017 Dec 19. Oncotarget. 2017. PMID: 29340013 Free PMC article.
Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy.
Talarico C, D'Antona L, Scumaci D, Barone A, Gigliotti F, Fiumara CV, Dattilo V, Gallo E, Visca P, Ortuso F, Abbruzzese C, Botta L, Schenone S, Cuda G, Alcaro S, Bianco C, Lavia P, Paggi MG, Perrotti N, Amato R. Talarico C, et al. Among authors: perrotti n. Oncotarget. 2015 Nov 10;6(35):37511-25. doi: 10.18632/oncotarget.5527. Oncotarget. 2015. PMID: 26462020 Free PMC article.
SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells.
Talarico C, Dattilo V, D'Antona L, Barone A, Amodio N, Belviso S, Musumeci F, Abbruzzese C, Bianco C, Trapasso F, Schenone S, Alcaro S, Ortuso F, Florio T, Paggi MG, Perrotti N, Amato R. Talarico C, et al. Among authors: perrotti n. Oncotarget. 2016 Mar 29;7(13):15868-84. doi: 10.18632/oncotarget.7520. Oncotarget. 2016. PMID: 26908461 Free PMC article.
107 results