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ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling.
Marriott S, Baskir RS, Gaskill C, Menon S, Carrier EJ, Williams J, Talati M, Helm K, Alford CE, Kropski JA, Loyd J, Wheeler L, Johnson J, Austin E, Nozik-Grayck E, Meyrick B, West JD, Klemm DJ, Majka SM. Marriott S, et al. Among authors: klemm dj. Am J Physiol Cell Physiol. 2014 Oct 15;307(8):C684-98. doi: 10.1152/ajpcell.00114.2014. Am J Physiol Cell Physiol. 2014. PMID: 25122876 Free PMC article.
Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension.
West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM. West JD, et al. Among authors: klemm dj. Am J Physiol Cell Physiol. 2014 Sep 1;307(5):C415-30. doi: 10.1152/ajpcell.00057.2014. Epub 2014 May 28. Am J Physiol Cell Physiol. 2014. PMID: 24871858 Free PMC article.
Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction.
Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM. Gaskill CF, et al. Among authors: klemm dj. J Clin Invest. 2017 Jun 1;127(6):2262-2276. doi: 10.1172/JCI88629. Epub 2017 May 2. J Clin Invest. 2017. PMID: 28463231 Free PMC article.
The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation.
Jun D, Garat C, West J, Thorn N, Chow K, Cleaver T, Sullivan T, Torchia EC, Childs C, Shade T, Tadjali M, Lara A, Nozik-Grayck E, Malkoski S, Sorrentino B, Meyrick B, Klemm D, Rojas M, Wagner DH Jr, Majka SM. Jun D, et al. Stem Cells. 2011 Apr;29(4):725-35. doi: 10.1002/stem.604. Stem Cells. 2011. PMID: 21312316 Free PMC article.
Shared gene expression patterns in mesenchymal progenitors derived from lung and epidermis in pulmonary arterial hypertension: identifying key pathways in pulmonary vascular disease.
Gaskill C, Marriott S, Pratap S, Menon S, Hedges LK, Fessel JP, Kropski JA, Ames D, Wheeler L, Loyd JE, Hemnes AR, Roop DR, Klemm DJ, Austin ED, Majka SM. Gaskill C, et al. Among authors: klemm dj. Pulm Circ. 2016 Dec;6(4):483-497. doi: 10.1086/688314. Pulm Circ. 2016. PMID: 28090290 Free PMC article.
Inactivation of Tsc2 in Abcg2 lineage-derived cells drives the appearance of polycystic lesions and fibrosis in the adult kidney.
Gewin LS, Summers ME, Harral JW, Gaskill CF, Khodo SN, Neelisetty S, Sullivan TM, Hopp K, Reese JJ, Klemm DJ, Kon V, Ess KC, Shi W, Majka SM. Gewin LS, et al. Among authors: klemm dj. Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1201-F1210. doi: 10.1152/ajprenal.00629.2018. Epub 2019 Aug 28. Am J Physiol Renal Physiol. 2019. PMID: 31461347 Free PMC article.
Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling.
Summers ME, Richmond BW, Menon S, Sheridan RM, Kropski JA, Majka SA, Taketo MM, Bastarache JA, West JD, De Langhe S, Geraghty P, Klemm DJ, Chu HW, Friedman RS, Tao YK, Foronjy RF, Majka SM. Summers ME, et al. Among authors: klemm dj. FASEB J. 2020 Aug;34(8):10267-10285. doi: 10.1096/fj.202000629R. Epub 2020 Jun 13. FASEB J. 2020. PMID: 32533805 Free PMC article.
85 results