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RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.
Takahashi N, Vereecke L, Bertrand MJ, Duprez L, Berger SB, Divert T, Gonçalves A, Sze M, Gilbert B, Kourula S, Goossens V, Lefebvre S, Günther C, Becker C, Bertin J, Gough PJ, Declercq W, van Loo G, Vandenabeele P. Takahashi N, et al. Among authors: goncalves a. Nature. 2014 Sep 4;513(7516):95-9. doi: 10.1038/nature13706. Nature. 2014. PMID: 25186904
Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis.
Remijsen Q, Goossens V, Grootjans S, Van den Haute C, Vanlangenakker N, Dondelinger Y, Roelandt R, Bruggeman I, Goncalves A, Bertrand MJ, Baekelandt V, Takahashi N, Berghe TV, Vandenabeele P. Remijsen Q, et al. Among authors: goncalves a. Cell Death Dis. 2014 Jan 16;5(1):e1004. doi: 10.1038/cddis.2013.531. Cell Death Dis. 2014. PMID: 24434512 Free PMC article.
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.
Dondelinger Y, Declercq W, Montessuit S, Roelandt R, Goncalves A, Bruggeman I, Hulpiau P, Weber K, Sehon CA, Marquis RW, Bertin J, Gough PJ, Savvides S, Martinou JC, Bertrand MJ, Vandenabeele P. Dondelinger Y, et al. Among authors: goncalves a. Cell Rep. 2014 May 22;7(4):971-81. doi: 10.1016/j.celrep.2014.04.026. Epub 2014 May 9. Cell Rep. 2014. PMID: 24813885 Free article.
The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D.
Teufelberger AR, Nordengrün M, Braun H, Maes T, De Grove K, Holtappels G, O'Brien C, Provoost S, Hammad H, Gonçalves A, Beyaert R, Declercq W, Vandenabeele P, Krysko DV, Bröker BM, Bachert C, Krysko O. Teufelberger AR, et al. Among authors: goncalves a. J Allergy Clin Immunol. 2018 Feb;141(2):549-559.e7. doi: 10.1016/j.jaci.2017.05.004. Epub 2017 May 19. J Allergy Clin Immunol. 2018. PMID: 28532656
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.
Voet S, Mc Guire C, Hagemeyer N, Martens A, Schroeder A, Wieghofer P, Daems C, Staszewski O, Vande Walle L, Jordao MJC, Sze M, Vikkula HK, Demeestere D, Van Imschoot G, Scott CL, Hoste E, Gonçalves A, Guilliams M, Lippens S, Libert C, Vandenbroucke RE, Kim KW, Jung S, Callaerts-Vegh Z, Callaerts P, de Wit J, Lamkanfi M, Prinz M, van Loo G. Voet S, et al. Among authors: goncalves a. Nat Commun. 2018 May 23;9(1):2036. doi: 10.1038/s41467-018-04376-5. Nat Commun. 2018. PMID: 29789522 Free PMC article.
Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation.
Hoste E, Maueröder C, van Hove L, Catrysse L, Vikkula HK, Sze M, Maes B, Karjosukarso D, Martens L, Gonçalves A, Parthoens E, Roelandt R, Declercq W, Fuentes I, Palisson F, Gonzalez S, Salas-Alanis JC, Boon L, Huebener P, Mulder KW, Ravichandran K, Saeys Y, Schwabe RF, van Loo G. Hoste E, et al. Among authors: goncalves a. Cell Rep. 2019 Nov 26;29(9):2689-2701.e4. doi: 10.1016/j.celrep.2019.10.104. Cell Rep. 2019. PMID: 31775038 Free article.
Microbes exploit death-induced nutrient release by gut epithelial cells.
Anderson CJ, Medina CB, Barron BJ, Karvelyte L, Aaes TL, Lambertz I, Perry JSA, Mehrotra P, Gonçalves A, Lemeire K, Blancke G, Andries V, Ghazavi F, Martens A, van Loo G, Vereecke L, Vandenabeele P, Ravichandran KS. Anderson CJ, et al. Among authors: goncalves a. Nature. 2021 Aug;596(7871):262-267. doi: 10.1038/s41586-021-03785-9. Epub 2021 Aug 4. Nature. 2021. PMID: 34349263
Type 1 immunity enables neonatal thymic ILC1 production.
Tougaard P, Ruiz Pérez M, Steels W, Huysentruyt J, Verstraeten B, Vetters J, Divert T, Gonçalves A, Roelandt R, Takahashi N, Janssens S, Buus TB, Taghon T, Leclercq G, Vandenabeele P. Tougaard P, et al. Among authors: goncalves a. Sci Adv. 2024 Jan 19;10(3):eadh5520. doi: 10.1126/sciadv.adh5520. Epub 2024 Jan 17. Sci Adv. 2024. PMID: 38232171 Free PMC article.
2,869 results