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A robust small-molecule microarray platform for screening cell lysates.
Bradner JE, McPherson OM, Mazitschek R, Barnes-Seeman D, Shen JP, Dhaliwal J, Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P, Schreiber SL, Koehler AN. Bradner JE, et al. Among authors: koehler an. Chem Biol. 2006 May;13(5):493-504. doi: 10.1016/j.chembiol.2006.03.004. Chem Biol. 2006. PMID: 16720270
A pipeline for ligand discovery using small-molecule microarrays.
Duffner JL, Clemons PA, Koehler AN. Duffner JL, et al. Among authors: koehler an. Curr Opin Chem Biol. 2007 Feb;11(1):74-82. doi: 10.1016/j.cbpa.2006.11.031. Epub 2006 Dec 13. Curr Opin Chem Biol. 2007. PMID: 17169601 Review.
Small-molecule microarrays as tools in ligand discovery.
Vegas AJ, Fuller JH, Koehler AN. Vegas AJ, et al. Among authors: koehler an. Chem Soc Rev. 2008 Jul;37(7):1385-94. doi: 10.1039/b703568n. Epub 2008 May 20. Chem Soc Rev. 2008. PMID: 18568164 Free PMC article. Review.
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. Stanton BZ, et al. Among authors: koehler an. Nat Chem Biol. 2009 Mar;5(3):154-6. doi: 10.1038/nchembio.142. Epub 2009 Jan 18. Nat Chem Biol. 2009. PMID: 19151731 Free PMC article.
Ligand discovery using small-molecule microarrays.
Casalena DE, Wassaf D, Koehler AN. Casalena DE, et al. Among authors: koehler an. Methods Mol Biol. 2012;803:249-63. doi: 10.1007/978-1-61779-364-6_17. Methods Mol Biol. 2012. PMID: 22065230
80 results