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Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia.
Huelsemann MF, Patz M, Beckmann L, Brinkmann K, Otto T, Fandrey J, Becker HJ, Theurich S, von Bergwelt-Baildon M, Pallasch CP, Zahedi RP, Kashkar H, Reinhardt HC, Hallek M, Wendtner CM, Frenzel LP. Huelsemann MF, et al. Among authors: brinkmann k. Leukemia. 2015 Apr;29(4):981-4. doi: 10.1038/leu.2014.320. Epub 2014 Nov 7. Leukemia. 2015. PMID: 25376373 No abstract available.
Elevated XIAP expression alone does not confer chemoresistance.
Seeger JM, Brinkmann K, Yazdanpanah B, Haubert D, Pongratz C, Coutelle O, Krönke M, Kashkar H. Seeger JM, et al. Among authors: brinkmann k. Br J Cancer. 2010 Jun 8;102(12):1717-23. doi: 10.1038/sj.bjc.6605704. Epub 2010 May 18. Br J Cancer. 2010. PMID: 20485285 Free PMC article.
Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing.
Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, Kashkar H. Coutelle O, et al. Among authors: brinkmann k. EMBO Mol Med. 2014 May;6(5):624-39. doi: 10.1002/emmm.201303016. EMBO Mol Med. 2014. PMID: 24648500 Free PMC article.
Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA.
Brinkmann K, Zigrino P, Witt A, Schell M, Ackermann L, Broxtermann P, Schüll S, Andree M, Coutelle O, Yazdanpanah B, Seeger JM, Klubertz D, Drebber U, Hacker UT, Krönke M, Mauch C, Hoppe T, Kashkar H. Brinkmann K, et al. Cell Rep. 2013 Mar 28;3(3):881-91. doi: 10.1016/j.celrep.2013.02.014. Epub 2013 Mar 14. Cell Rep. 2013. PMID: 23499448 Free article.
133 results