Letai A - Search Results

1

Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.

Dutta S, Ryan J, Chen TS, Kougentakis C, Letai A, Keating AE. Dutta S, et al. Among authors: letai a. J Mol Biol. 2015 Mar 27;427(6 Pt B):1241-1253. doi: 10.1016/j.jmb.2014.09.030. Epub 2014 Nov 14. J Mol Biol. 2015. PMID: 25451027 Free PMC article.

2

BH3 domains as BCL-2 inhibitors: prototype cancer therapeutics.

Letai A. Letai A. Expert Opin Biol Ther. 2003 Apr;3(2):293-304. doi: 10.1517/14712598.3.2.293. Expert Opin Biol Ther. 2003. PMID: 12662143

3

Antiapoptotic BCL-2 is required for maintenance of a model leukemia.

Letai A, Sorcinelli MD, Beard C, Korsmeyer SJ. Letai A, et al. Cancer Cell. 2004 Sep;6(3):241-9. doi: 10.1016/j.ccr.2004.07.011. Cancer Cell. 2004. PMID: 15380515 Free article.

4

BCL-2: found bound and drugged!

Letai A. Letai A. Trends Mol Med. 2005 Oct;11(10):442-4. doi: 10.1016/j.molmed.2005.08.007. Trends Mol Med. 2005. PMID: 16150641 Review.

5

Pharmacological manipulation of Bcl-2 family members to control cell death.

Letai A. Letai A. J Clin Invest. 2005 Oct;115(10):2648-55. doi: 10.1172/JCI26250. J Clin Invest. 2005. PMID: 16200198 Free PMC article.

6

Growth factor withdrawal and apoptosis: the middle game.

Letai A. Letai A. Mol Cell. 2006 Mar 17;21(6):728-30. doi: 10.1016/j.molcel.2006.03.005. Mol Cell. 2006. PMID: 16543140 Free article. Review.

7

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.

Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A. Certo M, et al. Among authors: letai a. Cancer Cell. 2006 May;9(5):351-65. doi: 10.1016/j.ccr.2006.03.027. Cancer Cell. 2006. PMID: 16697956 Free article.

8

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

Del Gaizo Moore V, Brown JR, Certo M, Love TM, Novina CD, Letai A. Del Gaizo Moore V, et al. Among authors: letai a. J Clin Invest. 2007 Jan;117(1):112-21. doi: 10.1172/JCI28281. J Clin Invest. 2007. PMID: 17200714 Free PMC article.

9

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents.

Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A. Deng J, et al. Among authors: letai a. Cancer Cell. 2007 Aug;12(2):171-85. doi: 10.1016/j.ccr.2007.07.001. Cancer Cell. 2007. PMID: 17692808 Free article.

10

BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.

Del Gaizo Moore V, Schlis KD, Sallan SE, Armstrong SA, Letai A. Del Gaizo Moore V, et al. Among authors: letai a. Blood. 2008 Feb 15;111(4):2300-9. doi: 10.1182/blood-2007-06-098012. Epub 2007 Dec 4. Blood. 2008. PMID: 18056841 Free PMC article.

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