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135,568 results

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Discovery of potent iminoheterocycle BACE1 inhibitors.
Caldwell JP, Mazzola RD, Durkin J, Chen J, Chen X, Favreau L, Kennedy M, Kuvelkar R, Lee J, McHugh N, McKittrick B, Orth P, Stamford A, Strickland C, Voigt J, Wang L, Zhang L, Zhang Q, Zhu Z. Caldwell JP, et al. Among authors: chen j, chen x. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5455-9. doi: 10.1016/j.bmcl.2014.10.006. Epub 2014 Oct 23. Bioorg Med Chem Lett. 2014. PMID: 25455483
Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse.
Hyde LA, McHugh NA, Chen J, Zhang Q, Manfra D, Nomeir AA, Josien H, Bara T, Clader JW, Zhang L, Parker EM, Higgins GA. Hyde LA, et al. Among authors: chen j. J Pharmacol Exp Ther. 2006 Dec;319(3):1133-43. doi: 10.1124/jpet.106.111716. Epub 2006 Aug 31. J Pharmacol Exp Ther. 2006. PMID: 16946102
In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects.
Hyde LA, Zhang Q, Del Vecchio RA, Leach PT, Cohen-Williams ME, Chen L, Wong GT, McHugh NA, Chen J, Higgins GA, Asberom T, Li W, Pissarnitski D, Levitan D, Nomeir AA, Clader JW, Zhang L, Parker EM. Hyde LA, et al. Among authors: chen j, chen l. Int J Alzheimers Dis. 2013;2013:823528. doi: 10.1155/2013/823528. Epub 2013 Mar 14. Int J Alzheimers Dis. 2013. PMID: 23573456 Free PMC article.
Fine Particulate Matter, Its Constituents, and Spontaneous Preterm Birth.
Jiao A, Reilly AN, Benmarhnia T, Sun Y, Avila C, Chiu V, Slezak J, Sacks DA, Molitor J, Li M, Chen JC, Wu J, Getahun D. Jiao A, et al. Among authors: chen jc. JAMA Netw Open. 2024 Nov 4;7(11):e2444593. doi: 10.1001/jamanetworkopen.2024.44593. JAMA Netw Open. 2024. PMID: 39535795
Recent Developments in Glioblastoma-On-A-Chip for Advanced Drug Screening Applications.
Maity S, Bhuyan T, Jewell C, Kawakita S, Sharma S, Nguyen HT, Hassani Najafabadi A, Ermis M, Falcone N, Chen J, Mandal K, Khorsandi D, Yilgor C, Choroomi A, Torres E, Mecwan M, John JV, Akbari M, Wang Z, Moniz-Garcia D, Quiñones-Hinojosa A, Jucaud V, Dokmeci MR, Khademhosseini A. Maity S, et al. Among authors: chen j. Small. 2024 Nov 13:e2405511. doi: 10.1002/smll.202405511. Online ahead of print. Small. 2024. PMID: 39535474 Review.
135,568 results
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