O'Brien TP - Search Results

1

Comparison of the physiological relevance of systemic vs. portal insulin delivery to evaluate whole body glucose flux during an insulin clamp.

Farmer TD, Jenkins EC, O'Brien TP, McCoy GA, Havlik AE, Nass ER, Nicholson WE, Printz RL, Shiota M. Farmer TD, et al. Am J Physiol Endocrinol Metab. 2015 Feb 1;308(3):E206-22. doi: 10.1152/ajpendo.00406.2014. Epub 2014 Dec 16. Am J Physiol Endocrinol Metab. 2015. PMID: 25516552 Free PMC article.

2

G6PC2: a negative regulator of basal glucose-stimulated insulin secretion.

Pound LD, Oeser JK, O'Brien TP, Wang Y, Faulman CJ, Dadi PK, Jacobson DA, Hutton JC, McGuinness OP, Shiota M, O'Brien RM. Pound LD, et al. Diabetes. 2013 May;62(5):1547-56. doi: 10.2337/db12-1067. Epub 2012 Dec 28. Diabetes. 2013. PMID: 23274894 Free PMC article.

3

Glucotoxicity targets hepatic glucokinase in Zucker diabetic fatty rats, a model of type 2 diabetes associated with obesity.

Ueta K, O'Brien TP, McCoy GA, Kim K, Healey EC, Farmer TD, Donahue EP, Condren AB, Printz RL, Shiota M. Ueta K, et al. Am J Physiol Endocrinol Metab. 2014 Jun 1;306(11):E1225-38. doi: 10.1152/ajpendo.00507.2013. Epub 2014 Apr 8. Am J Physiol Endocrinol Metab. 2014. PMID: 24714398 Free PMC article.

4

Correcting Postprandial Hyperglycemia in Zucker Diabetic Fatty Rats With an SGLT2 Inhibitor Restores Glucose Effectiveness in the Liver and Reduces Insulin Resistance in Skeletal Muscle.

O'Brien TP, Jenkins EC, Estes SK, Castaneda AV, Ueta K, Farmer TD, Puglisi AE, Swift LL, Printz RL, Shiota M. O'Brien TP, et al. Diabetes. 2017 May;66(5):1172-1184. doi: 10.2337/db16-1410. Epub 2017 Feb 28. Diabetes. 2017. PMID: 28246292 Free PMC article.

5

Genome-wide gene expression changes associated with exposure of rat liver, heart, and kidney cells to endosulfan.

Liu R, Printz RL, Jenkins EC, O'Brien TP, Te JA, Shiota M, Wallqvist A. Liu R, et al. Toxicol In Vitro. 2018 Apr;48:244-254. doi: 10.1016/j.tiv.2018.01.022. Epub 2018 Jan 31. Toxicol In Vitro. 2018. PMID: 29391264

6

Metabolic network-based predictions of toxicant-induced metabolite changes in the laboratory rat.

Pannala VR, Wall ML, Estes SK, Trenary I, O'Brien TP, Printz RL, Vinnakota KC, Reifman J, Shiota M, Young JD, Wallqvist A. Pannala VR, et al. Sci Rep. 2018 Aug 3;8(1):11678. doi: 10.1038/s41598-018-30149-7. Sci Rep. 2018. PMID: 30076366 Free PMC article.

7

Network Modeling of Liver Metabolism to Predict Plasma Metabolite Changes During Short-Term Fasting in the Laboratory Rat.

Vinnakota KC, Pannala VR, Wall ML, Rahim M, Estes SK, Trenary I, O'Brien TP, Printz RL, Reifman J, Shiota M, Young JD, Wallqvist A. Vinnakota KC, et al. Front Physiol. 2019 Mar 1;10:161. doi: 10.3389/fphys.2019.00161. eCollection 2019. Front Physiol. 2019. PMID: 30881311 Free PMC article.

8

Mechanistic identification of biofluid metabolite changes as markers of acetaminophen-induced liver toxicity in rats.

Pannala VR, Vinnakota KC, Rawls KD, Estes SK, O'Brien TP, Printz RL, Papin JA, Reifman J, Shiota M, Young JD, Wallqvist A. Pannala VR, et al. Toxicol Appl Pharmacol. 2019 Jun 1;372:19-32. doi: 10.1016/j.taap.2019.04.001. Epub 2019 Apr 8. Toxicol Appl Pharmacol. 2019. PMID: 30974156 Free PMC article.

9

Genome-Scale Model-Based Identification of Metabolite Indicators for Early Detection of Kidney Toxicity.

Pannala VR, Vinnakota KC, Estes SK, Trenary I, OˈBrien TP, Printz RL, Papin JA, Reifman J, Oyama T, Shiota M, Young JD, Wallqvist A. Pannala VR, et al. Toxicol Sci. 2020 Feb 1;173(2):293-312. doi: 10.1093/toxsci/kfz228. Toxicol Sci. 2020. PMID: 31722432 Free PMC article.

10

Assessing Chemical-Induced Liver Injury In Vivo From In Vitro Gene Expression Data in the Rat: The Case of Thioacetamide Toxicity.

Schyman P, Printz RL, Estes SK, O'Brien TP, Shiota M, Wallqvist A. Schyman P, et al. Front Genet. 2019 Nov 26;10:1233. doi: 10.3389/fgene.2019.01233. eCollection 2019. Front Genet. 2019. PMID: 31850077 Free PMC article.

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