Zhao JJ - Search Results

1

PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.

Thorpe LM, Yuzugullu H, Zhao JJ. Thorpe LM, et al. Among authors: zhao jj. Nat Rev Cancer. 2015 Jan;15(1):7-24. doi: 10.1038/nrc3860. Nat Rev Cancer. 2015. PMID: 25533673 Free PMC article. Review.

2

The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation.

Zhao JJ, Cheng H, Jia S, Wang L, Gjoerup OV, Mikami A, Roberts TM. Zhao JJ, et al. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16296-300. doi: 10.1073/pnas.0607899103. Epub 2006 Oct 23. Proc Natl Acad Sci U S A. 2006. PMID: 17060635 Free PMC article.

3

PI3 kinases in cancer: from oncogene artifact to leading cancer target.

Zhao JJ, Roberts TM. Zhao JJ, et al. Sci STKE. 2006 Dec 12;2006(365):pe52. doi: 10.1126/stke.3652006pe52. Sci STKE. 2006. PMID: 17164467

4

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.

Jia S, Liu Z, Zhang S, Liu P, Zhang L, Lee SH, Zhang J, Signoretti S, Loda M, Roberts TM, Zhao JJ. Jia S, et al. Among authors: zhao jj. Nature. 2008 Aug 7;454(7205):776-9. doi: 10.1038/nature07091. Epub 2008 Jun 25. Nature. 2008. PMID: 18594509 Free PMC article.

5

Should individual PI3 kinase isoforms be targeted in cancer?

Jia S, Roberts TM, Zhao JJ. Jia S, et al. Among authors: zhao jj. Curr Opin Cell Biol. 2009 Apr;21(2):199-208. doi: 10.1016/j.ceb.2008.12.007. Epub 2009 Feb 4. Curr Opin Cell Biol. 2009. PMID: 19200708 Free PMC article. Review.

6

Targeting the phosphoinositide 3-kinase pathway in cancer.

Liu P, Cheng H, Roberts TM, Zhao JJ. Liu P, et al. Among authors: zhao jj. Nat Rev Drug Discov. 2009 Aug;8(8):627-44. doi: 10.1038/nrd2926. Nat Rev Drug Discov. 2009. PMID: 19644473 Free PMC article. Review.

7

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.

Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA. Johannessen CM, et al. Among authors: zhao jj. Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627. Epub 2010 Nov 24. Nature. 2010. PMID: 21107320 Free PMC article.

8

Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms.

Liu P, Cheng H, Santiago S, Raeder M, Zhang F, Isabella A, Yang J, Semaan DJ, Chen C, Fox EA, Gray NS, Monahan J, Schlegel R, Beroukhim R, Mills GB, Zhao JJ. Liu P, et al. Among authors: zhao jj. Nat Med. 2011 Aug 7;17(9):1116-20. doi: 10.1038/nm.2402. Nat Med. 2011. PMID: 21822287 Free PMC article.

9

Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent.

Ni J, Liu Q, Xie S, Carlson C, Von T, Vogel K, Riddle S, Benes C, Eck M, Roberts T, Gray N, Zhao J. Ni J, et al. Cancer Discov. 2012 May;2(5):425-33. doi: 10.1158/2159-8290.CD-12-0003. Epub 2012 Apr 12. Cancer Discov. 2012. PMID: 22588880 Free PMC article.

10

The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.

Utermark T, Rao T, Cheng H, Wang Q, Lee SH, Wang ZC, Iglehart JD, Roberts TM, Muller WJ, Zhao JJ. Utermark T, et al. Among authors: zhao jj. Genes Dev. 2012 Jul 15;26(14):1573-86. doi: 10.1101/gad.191973.112. Genes Dev. 2012. PMID: 22802530 Free PMC article.

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