Werz O - Search Results

1

SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.

Flesch D, Ness J, Lamers C, Dehm F, Popella S, Steri R, Ogorek I, Hieke M, Dannhardt G, Werz O, Weggen S, Schubert-Zsilavecz M. Flesch D, et al. Among authors: werz o. Bioorg Med Chem Lett. 2015 Feb 15;25(4):841-6. doi: 10.1016/j.bmcl.2014.12.073. Epub 2014 Dec 30. Bioorg Med Chem Lett. 2015. PMID: 25575659

2

Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization.

Altmann A, Fischer L, Schubert-Zsilavecz M, Steinhilber D, Werz O. Altmann A, et al. Among authors: werz o. Biochem Biophys Res Commun. 2002 Jan 11;290(1):185-90. doi: 10.1006/bbrc.2001.6153. Biochem Biophys Res Commun. 2002. PMID: 11779151

3

Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes.

Altmann A, Poeckel D, Fischer L, Schubert-Zsilavecz M, Steinhilber D, Werz O. Altmann A, et al. Among authors: werz o. Br J Pharmacol. 2004 Jan;141(2):223-32. doi: 10.1038/sj.bjp.0705604. Epub 2003 Dec 22. Br J Pharmacol. 2004. PMID: 14691050 Free PMC article.

4

Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase.

Landwehr J, George S, Karg EM, Poeckel D, Steinhilber D, Troschuetz R, Werz O. Landwehr J, et al. Among authors: werz o. J Med Chem. 2006 Jul 13;49(14):4327-32. doi: 10.1021/jm050801i. J Med Chem. 2006. PMID: 16821792

5

Inhibition of human 5-lipoxygenase and anti-neoplastic effects by 2-amino-1,4-benzoquinones.

Poeckel D, Niedermeyer TH, Pham HT, Mikolasch A, Mundt S, Lindequist U, Lalk M, Werz O. Poeckel D, et al. Among authors: werz o. Med Chem. 2006 Nov;2(6):591-5. doi: 10.2174/1573406410602060591. Med Chem. 2006. PMID: 17105440

6

Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening.

Franke L, Schwarz O, Müller-Kuhrt L, Hoernig C, Fischer L, George S, Tanrikulu Y, Schneider P, Werz O, Steinhilber D, Schneider G. Franke L, et al. Among authors: werz o. J Med Chem. 2007 May 31;50(11):2640-6. doi: 10.1021/jm060655w. Epub 2007 Apr 27. J Med Chem. 2007. PMID: 17461565

7

Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes.

Poeckel D, Greiner C, Verhoff M, Rau O, Tausch L, Hörnig C, Steinhilber D, Schubert-Zsilavecz M, Werz O. Poeckel D, et al. Among authors: werz o. Biochem Pharmacol. 2008 Jul 1;76(1):91-7. doi: 10.1016/j.bcp.2008.04.013. Epub 2008 May 1. Biochem Pharmacol. 2008. PMID: 18508031

8

Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.

Werz O, Greiner C, Koeberle A, Hoernig C, George S, Popescu L, Syha I, Schubert-Zsilavecz M, Steinhilber D. Werz O, et al. J Med Chem. 2008 Sep 11;51(17):5449-53. doi: 10.1021/jm800588x. Epub 2008 Aug 19. J Med Chem. 2008. PMID: 18710209

9

Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

Koeberle A, Zettl H, Greiner C, Wurglics M, Schubert-Zsilavecz M, Werz O. Koeberle A, et al. Among authors: werz o. J Med Chem. 2008 Dec 25;51(24):8068-76. doi: 10.1021/jm801085s. J Med Chem. 2008. PMID: 19053751

10

Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.

Karg EM, Luderer S, Pergola C, Bühring U, Rossi A, Northoff H, Sautebin L, Troschütz R, Werz O. Karg EM, et al. Among authors: werz o. J Med Chem. 2009 Jun 11;52(11):3474-83. doi: 10.1021/jm900212y. J Med Chem. 2009. PMID: 19492852 Free article.

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