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CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo.
Gregory GP, Hogg SJ, Kats LM, Vidacs E, Baker AJ, Gilan O, Lefebure M, Martin BP, Dawson MA, Johnstone RW, Shortt J. Gregory GP, et al. Among authors: johnstone rw. Leukemia. 2015 Jun;29(6):1437-41. doi: 10.1038/leu.2015.10. Epub 2014 Jan 12. Leukemia. 2015. PMID: 25578475 Free PMC article. No abstract available.
Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist.
Frew AJ, Lindemann RK, Martin BP, Clarke CJ, Sharkey J, Anthony DA, Banks KM, Haynes NM, Gangatirkar P, Stanley K, Bolden JE, Takeda K, Yagita H, Secrist JP, Smyth MJ, Johnstone RW. Frew AJ, et al. Among authors: johnstone rw. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11317-22. doi: 10.1073/pnas.0801868105. Epub 2008 Aug 6. Proc Natl Acad Sci U S A. 2008. PMID: 18685088 Free PMC article.
E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis.
Wolyniec K, Shortt J, de Stanchina E, Levav-Cohen Y, Alsheich-Bartok O, Louria-Hayon I, Corneille V, Kumar B, Woods SJ, Opat S, Johnstone RW, Scott CL, Segal D, Pandolfi PP, Fox S, Strasser A, Jiang YH, Lowe SW, Haupt S, Haupt Y. Wolyniec K, et al. Among authors: johnstone rw. Blood. 2012 Jul 26;120(4):822-32. doi: 10.1182/blood-2011-10-387647. Epub 2012 Jun 11. Blood. 2012. PMID: 22689861 Free PMC article.
Oncogenes in cell survival and cell death.
Shortt J, Johnstone RW. Shortt J, et al. Among authors: johnstone rw. Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12):a009829. doi: 10.1101/cshperspect.a009829. Cold Spring Harb Perspect Biol. 2012. PMID: 23209150 Free PMC article. Review.
The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence.
Wall M, Poortinga G, Stanley KL, Lindemann RK, Bots M, Chan CJ, Bywater MJ, Kinross KM, Astle MV, Waldeck K, Hannan KM, Shortt J, Smyth MJ, Lowe SW, Hannan RD, Pearson RB, Johnstone RW, McArthur GA. Wall M, et al. Among authors: johnstone rw. Cancer Discov. 2013 Jan;3(1):82-95. doi: 10.1158/2159-8290.CD-12-0404. Epub 2012 Dec 14. Cancer Discov. 2013. PMID: 23242809 Free PMC article.
288 results