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233 results

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Page 1
Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation.
Varelias A, Gartlan KH, Kreijveld E, Olver SD, Lor M, Kuns RD, Lineburg KE, Teal BE, Raffelt NC, Cheong M, Alexander KA, Koyama M, Markey KA, Sturgeon E, Leach J, Reddy P, Kennedy GA, Yanik GA, Blazar BR, Tey SK, Clouston AD, MacDonald KP, Cooke KR, Hill GR. Varelias A, et al. Among authors: alexander ka. Blood. 2015 Apr 9;125(15):2435-44. doi: 10.1182/blood-2014-07-590232. Epub 2015 Feb 11. Blood. 2015. PMID: 25673640 Free PMC article.
Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation.
Robb RJ, Lineburg KE, Kuns RD, Wilson YA, Raffelt NC, Olver SD, Varelias A, Alexander KA, Teal BE, Sparwasser T, Hammerling GJ, Markey KA, Koyama M, Clouston AD, Engwerda CR, Hill GR, MacDonald KP. Robb RJ, et al. Among authors: alexander ka. Blood. 2012 Jun 14;119(24):5898-908. doi: 10.1182/blood-2011-12-396119. Epub 2012 Apr 26. Blood. 2012. PMID: 22538855 Free article.
Promoting regulation via the inhibition of DNAM-1 after transplantation.
Koyama M, Kuns RD, Olver SD, Lineburg KE, Lor M, Teal BE, Raffelt NC, Leveque L, Chan CJ, Robb RJ, Markey KA, Alexander KA, Varelias A, Clouston AD, Smyth MJ, MacDonald KP, Hill GR. Koyama M, et al. Among authors: alexander ka. Blood. 2013 Apr 25;121(17):3511-20. doi: 10.1182/blood-2012-07-444026. Epub 2013 Feb 21. Blood. 2013. PMID: 23430112 Free article.
Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD.
Leveque-El Mouttie L, Koyama M, Le Texier L, Markey KA, Cheong M, Kuns RD, Lineburg KE, Teal BE, Alexander KA, Clouston AD, Blazar BR, Hill GR, MacDonald KP. Leveque-El Mouttie L, et al. Among authors: alexander ka. Blood. 2016 Aug 11;128(6):794-804. doi: 10.1182/blood-2015-11-680876. Epub 2016 Jun 23. Blood. 2016. PMID: 27338097 Free PMC article.
Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production.
Du J, Paz K, Flynn R, Vulic A, Robinson TM, Lineburg KE, Alexander KA, Meng J, Roy S, Panoskaltsis-Mortari A, Loschi M, Hill GR, Serody JS, Maillard I, Miklos D, Koreth J, Cutler CS, Antin JH, Ritz J, MacDonald KP, Schacker TW, Luznik L, Blazar BR. Du J, et al. Among authors: alexander ka. Blood. 2017 May 4;129(18):2570-2580. doi: 10.1182/blood-2017-01-758854. Epub 2017 Mar 2. Blood. 2017. PMID: 28254742 Free PMC article.
Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease.
Flynn R, Allen JL, Luznik L, MacDonald KP, Paz K, Alexander KA, Vulic A, Du J, Panoskaltsis-Mortari A, Taylor PA, Poe JC, Serody JS, Murphy WJ, Hill GR, Maillard I, Koreth J, Cutler CS, Soiffer RJ, Antin JH, Ritz J, Chao NJ, Clynes RA, Sarantopoulos S, Blazar BR. Flynn R, et al. Among authors: alexander ka. Blood. 2015 Jun 25;125(26):4085-94. doi: 10.1182/blood-2014-08-595470. Epub 2015 Apr 7. Blood. 2015. PMID: 25852057 Free PMC article.
Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease.
Le Texier L, Lineburg KE, Cao B, McDonald-Hyman C, Leveque-El Mouttie L, Nicholls J, Melino M, Nalkurthi BC, Alexander KA, Teal B, Blake SJ, Souza-Fonseca-Guimaraes F, Engwerda CR, Kuns RD, Lane SW, Teng M, Teh C, Gray D, Clouston AD, Nilsson SK, Blazar BR, Hill GR, MacDonald KP. Le Texier L, et al. Among authors: alexander ka. JCI Insight. 2016 Sep 22;1(15):e86850. doi: 10.1172/jci.insight.86850. JCI Insight. 2016. PMID: 27699243 Free PMC article.
CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease.
Alexander KA, Flynn R, Lineburg KE, Kuns RD, Teal BE, Olver SD, Lor M, Raffelt NC, Koyama M, Leveque L, Le Texier L, Melino M, Markey KA, Varelias A, Engwerda C, Serody JS, Janela B, Ginhoux F, Clouston AD, Blazar BR, Hill GR, MacDonald KP. Alexander KA, et al. J Clin Invest. 2014 Oct;124(10):4266-80. doi: 10.1172/JCI75935. Epub 2014 Aug 26. J Clin Invest. 2014. PMID: 25157821 Free PMC article.
Spatiotemporal Characterization of the Cellular and Molecular Contributors to Liver Fibrosis in a Murine Hepatotoxic-Injury Model.
Melino M, Gadd VL, Alexander KA, Beattie L, Lineburg KE, Martinez M, Teal B, Le Texier L, Irvine KM, Miller GC, Boyle GM, Hill GR, Clouston AD, Powell EE, MacDonald KP. Melino M, et al. Among authors: alexander ka. Am J Pathol. 2016 Mar;186(3):524-38. doi: 10.1016/j.ajpath.2015.10.029. Epub 2016 Jan 4. Am J Pathol. 2016. PMID: 26762581 Free article.
Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors.
Gartlan KH, Jaiswal JK, Bull MR, Akhlaghi H, Sutton VR, Alexander KA, Chang K, Hill GR, Miller CK, O'Connor PD, Jose J, Trapani JA, Charman SA, Spicer JA, Jamieson SMF. Gartlan KH, et al. Among authors: alexander ka. ACS Pharmacol Transl Sci. 2022 May 31;5(6):429-439. doi: 10.1021/acsptsci.2c00009. eCollection 2022 Jun 10. ACS Pharmacol Transl Sci. 2022. PMID: 35711815 Free PMC article.
233 results