Fray MJ - Search Results

1

Relative binding affinities of integrin antagonists by equilibrium dialysis and liquid chromatography-mass spectrometry.

Tipping WJ, Tshuma N, Adams J, Haywood HT, Rowedder JE, Fray MJ, McInally T, Macdonald SJ, Oldham NJ. Tipping WJ, et al. Among authors: fray mj. ACS Med Chem Lett. 2014 Dec 22;6(2):221-4. doi: 10.1021/ml500395v. eCollection 2015 Feb 12. ACS Med Chem Lett. 2014. PMID: 25699153 Free PMC article.

2

Structure Activity Relationships of αv Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents.

Adams J, Anderson EC, Blackham EE, Chiu YW, Clarke T, Eccles N, Gill LA, Haye JJ, Haywood HT, Hoenig CR, Kausas M, Le J, Russell HL, Smedley C, Tipping WJ, Tongue T, Wood CC, Yeung J, Rowedder JE, Fray MJ, McInally T, Macdonald SJ. Adams J, et al. Among authors: fray mj. ACS Med Chem Lett. 2014 Sep 19;5(11):1207-12. doi: 10.1021/ml5002079. eCollection 2014 Nov 13. ACS Med Chem Lett. 2014. PMID: 25408832 Free PMC article.

3

Passing on the medicinal chemistry baton: training undergraduates to be industry-ready through research projects between the University of Nottingham and GlaxoSmithKline.

Macdonald SJ, Fray MJ, McInally T. Macdonald SJ, et al. Among authors: fray mj. Drug Discov Today. 2016 Jun;21(6):880-7. doi: 10.1016/j.drudis.2016.01.015. Epub 2016 Feb 4. Drug Discov Today. 2016. PMID: 26852693 Review.

4

A practical drug discovery project at the undergraduate level.

Fray MJ, Macdonald SJ, Baldwin IR, Barton N, Brown J, Campbell IB, Churcher I, Coe DM, Cooper AW, Craven AP, Fisher G, Inglis GG, Kelly HA, Liddle J, Maxwell AC, Patel VK, Swanson S, Wellaway N. Fray MJ, et al. Drug Discov Today. 2013 Dec;18(23-24):1158-72. doi: 10.1016/j.drudis.2013.09.004. Epub 2013 Sep 16. Drug Discov Today. 2013. PMID: 24051399

5

Structure-activity relationships of 1,4-dihydro-(1H,4H)-quinoxaline-2,3-diones as N-methyl-D-aspartate (glycine site) receptor antagonists. 1. Heterocyclic substituted 5-alkyl derivatives.

Fray MJ, Bull DJ, Carr CL, Gautier EC, Mowbray CE, Stobie A. Fray MJ, et al. J Med Chem. 2001 Jun 7;44(12):1951-62. doi: 10.1021/jm001124p. J Med Chem. 2001. PMID: 11384240

6

N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.

Wakenhut F, Fish PV, Fray MJ, Gurrell I, Mills JE, Stobie A, Whitlock GA. Wakenhut F, et al. Among authors: fray mj. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4308-11. doi: 10.1016/j.bmcl.2008.06.078. Epub 2008 Jun 28. Bioorg Med Chem Lett. 2008. PMID: 18625557

7

Novel antagonists of platelet-activating factor. 2. Synthesis and structure-activity relationships of potent and long-acting heterofused [1,5]benzodiazepine and [1,4]diazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine.

Fray MJ, Bull DJ, Cooper K, Parry MJ, Stefaniak MH. Fray MJ, et al. J Med Chem. 1995 Sep 1;38(18):3524-35. doi: 10.1021/jm00018a012. J Med Chem. 1995. PMID: 7658439

8

1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives.

Cooper K, Fray MJ, Parry MJ, Richardson K, Steele J. Cooper K, et al. Among authors: fray mj. J Med Chem. 1992 Aug 21;35(17):3115-29. doi: 10.1021/jm00095a005. J Med Chem. 1992. PMID: 1507200

9

Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.

Fray MJ, Fish PV, Allan GA, Bish G, Clarke N, Eccles R, Harrison AC, Le Net JL, Phillips SC, Regan N, Sobry C, Stobie A, Wakenhut F, Westbrook D, Westbrook SL, Whitlock GA. Fray MJ, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. doi: 10.1016/j.bmcl.2010.04.052. Epub 2010 Apr 18. Bioorg Med Chem Lett. 2010. PMID: 20471260

10

A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers.

Fray MJ, Dickinson RP, Huggins JP, Occleston NL. Fray MJ, et al. J Med Chem. 2003 Jul 31;46(16):3514-25. doi: 10.1021/jm0308038. J Med Chem. 2003. PMID: 12877590

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