Blundell TL - Search Results

1

Mutations in the NHEJ component XRCC4 cause primordial dwarfism.

Murray JE, van der Burg M, IJspeert H, Carroll P, Wu Q, Ochi T, Leitch A, Miller ES, Kysela B, Jawad A, Bottani A, Brancati F, Cappa M, Cormier-Daire V, Deshpande C, Faqeih EA, Graham GE, Ranza E, Blundell TL, Jackson AP, Stewart GS, Bicknell LS. Murray JE, et al. Among authors: blundell tl. Am J Hum Genet. 2015 Mar 5;96(3):412-24. doi: 10.1016/j.ajhg.2015.01.013. Epub 2015 Feb 26. Am J Hum Genet. 2015. PMID: 25728776 Free PMC article.

2

Crystal structure of an Xrcc4-DNA ligase IV complex.

Sibanda BL, Critchlow SE, Begun J, Pei XY, Jackson SP, Blundell TL, Pellegrini L. Sibanda BL, et al. Among authors: blundell tl. Nat Struct Biol. 2001 Dec;8(12):1015-9. doi: 10.1038/nsb725. Nat Struct Biol. 2001. PMID: 11702069

3

Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.

Doré AS, Furnham N, Davies OR, Sibanda BL, Chirgadze DY, Jackson SP, Pellegrini L, Blundell TL. Doré AS, et al. Among authors: blundell tl. DNA Repair (Amst). 2006 Mar 7;5(3):362-8. doi: 10.1016/j.dnarep.2005.11.004. Epub 2006 Jan 18. DNA Repair (Amst). 2006. PMID: 16388993

4

Structural biology of DNA repair: spatial organisation of the multicomponent complexes of nonhomologous end joining.

Ochi T, Sibanda BL, Wu Q, Chirgadze DY, Bolanos-Garcia VM, Blundell TL. Ochi T, et al. Among authors: blundell tl. J Nucleic Acids. 2010 Aug 25;2010:621695. doi: 10.4061/2010/621695. J Nucleic Acids. 2010. PMID: 20862368 Free PMC article.

5

Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions.

Wu Q, Ochi T, Matak-Vinkovic D, Robinson CV, Chirgadze DY, Blundell TL. Wu Q, et al. Among authors: blundell tl. Biochem Soc Trans. 2011 Oct;39(5):1387-92, suppl 2 p following 1392. doi: 10.1042/BST0391387. Biochem Soc Trans. 2011. PMID: 21936820

6

Spatial and temporal organization of multi-protein assemblies: achieving sensitive control in information-rich cell-regulatory systems.

Bolanos-Garcia VM, Wu Q, Ochi T, Chirgadze DY, Sibanda BL, Blundell TL. Bolanos-Garcia VM, et al. Among authors: blundell tl. Philos Trans A Math Phys Eng Sci. 2012 Jun 28;370(1969):3023-39. doi: 10.1098/rsta.2011.0268. Philos Trans A Math Phys Eng Sci. 2012. PMID: 22615474

7

Structural insights into the role of domain flexibility in human DNA ligase IV.

Ochi T, Wu Q, Chirgadze DY, Grossmann JG, Bolanos-Garcia VM, Blundell TL. Ochi T, et al. Among authors: blundell tl. Structure. 2012 Jul 3;20(7):1212-22. doi: 10.1016/j.str.2012.04.012. Epub 2012 May 31. Structure. 2012. PMID: 22658747 Free PMC article.

8

Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair.

Ochi T, Gu X, Blundell TL. Ochi T, et al. Among authors: blundell tl. Structure. 2013 Apr 2;21(4):672-9. doi: 10.1016/j.str.2013.02.014. Epub 2013 Mar 21. Structure. 2013. PMID: 23523427 Free PMC article.

9

The spatial organization of non-homologous end joining: from bridging to end joining.

Ochi T, Wu Q, Blundell TL. Ochi T, et al. Among authors: blundell tl. DNA Repair (Amst). 2014 May;17(100):98-109. doi: 10.1016/j.dnarep.2014.02.010. Epub 2014 Mar 11. DNA Repair (Amst). 2014. PMID: 24636752 Free PMC article.

10

DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.

Ochi T, Blackford AN, Coates J, Jhujh S, Mehmood S, Tamura N, Travers J, Wu Q, Draviam VM, Robinson CV, Blundell TL, Jackson SP. Ochi T, et al. Among authors: blundell tl. Science. 2015 Jan 9;347(6218):185-188. doi: 10.1126/science.1261971. Science. 2015. PMID: 25574025 Free PMC article.

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